Hidden forces: the impact of cancer-associated fibroblasts on non-small cell lung cancer development and therapy

Hidden forces: the impact of cancer-associated fibroblasts on non-small cell lung cancer development and therapy

Abstract Non-small cell lung cancer (NSCLC) continues to be a leading cause of cancer-related deaths globally, primarily due to its late diagnosis and the complex nature of its tumor microenvironment (TME). Within this environment, cancer-associated fibroblasts (CAFs) play a crucial role in regulati...

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Bibliographic Details
Main Authors: Ziheng Wu, Meilin Luo, Huiyi Hu, Zhijun Jiang, Yinan Lu, Zhi-Jie Xiao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Non-small cell lung cancer
Cancer associated fibroblast
Heterogeneity
Immune suppression
Extracellular vesicles
Drug resistance
Online Access:https://doi.org/10.1186/s12967-025-06791-x
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