Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis
Diabetic macular edema (DME) is the main cause of blindness in individuals with diabetes mellitus (DM). This meta-analysis compared the effectiveness and safety of macular grid/focal photocoagulation with and without conbercept in the treatment of DME. Studies were identified through systematic sear...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/2256779 |
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| author | Xiaoyan Sun Wei Wei |
| author_facet | Xiaoyan Sun Wei Wei |
| author_sort | Xiaoyan Sun |
| collection | DOAJ |
| description | Diabetic macular edema (DME) is the main cause of blindness in individuals with diabetes mellitus (DM). This meta-analysis compared the effectiveness and safety of macular grid/focal photocoagulation with and without conbercept in the treatment of DME. Studies were identified through systematic searches of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database, Wanfang Data Knowledge Service Platform, and VIP Information Resource Integration Service Platform from their earliest records to June 2021. Twelve articles involving 2600 patients with DME were included. Results showed that patients receiving conbercept with macular grid/focal photocoagulation had a statistically significant reduction in central macular thickness (CMT) over macular grid/focal photocoagulation alone at 1 month and 3 months post procedure. Compared with the control group, the combination therapy group had a significantly increased level of effectiveness and best-corrected visual acuity (BCVA) compared with the control group. The combination therapy group significantly increased the level of effectiveness and best-corrected visual acuity (BCVA) compared with the control group. Conbercept with macular grid/focal photocoagulation was more effective than macular grid/focal photocoagulation alone in terms of functional outcomes for DME treatment. |
| format | Article |
| id | doaj-art-5f0be9f4b6ae425ca495b76e1584a58a |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-5f0be9f4b6ae425ca495b76e1584a58a2025-02-03T01:07:16ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/2256779Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-AnalysisXiaoyan Sun0Wei Wei1Department of OphthalmologyDepartment of OphthalmologyDiabetic macular edema (DME) is the main cause of blindness in individuals with diabetes mellitus (DM). This meta-analysis compared the effectiveness and safety of macular grid/focal photocoagulation with and without conbercept in the treatment of DME. Studies were identified through systematic searches of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database, Wanfang Data Knowledge Service Platform, and VIP Information Resource Integration Service Platform from their earliest records to June 2021. Twelve articles involving 2600 patients with DME were included. Results showed that patients receiving conbercept with macular grid/focal photocoagulation had a statistically significant reduction in central macular thickness (CMT) over macular grid/focal photocoagulation alone at 1 month and 3 months post procedure. Compared with the control group, the combination therapy group had a significantly increased level of effectiveness and best-corrected visual acuity (BCVA) compared with the control group. The combination therapy group significantly increased the level of effectiveness and best-corrected visual acuity (BCVA) compared with the control group. Conbercept with macular grid/focal photocoagulation was more effective than macular grid/focal photocoagulation alone in terms of functional outcomes for DME treatment.http://dx.doi.org/10.1155/2022/2256779 |
| spellingShingle | Xiaoyan Sun Wei Wei Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis Journal of Ophthalmology |
| title | Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis |
| title_full | Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis |
| title_fullStr | Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis |
| title_short | Intravitreal Conbercept with Grid/Focal Photocoagulation for the Treatment of Diabetic Macular Edema: A Systematic Review and Meta-Analysis |
| title_sort | intravitreal conbercept with grid focal photocoagulation for the treatment of diabetic macular edema a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2022/2256779 |
| work_keys_str_mv | AT xiaoyansun intravitrealconberceptwithgridfocalphotocoagulationforthetreatmentofdiabeticmacularedemaasystematicreviewandmetaanalysis AT weiwei intravitrealconberceptwithgridfocalphotocoagulationforthetreatmentofdiabeticmacularedemaasystematicreviewandmetaanalysis |