Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis
Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to Pseudomonas aeruginosa. Methods Retrospective chart review was conducted on consecutive patients with scleritis...
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Elsevier
2025-06-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001048 |
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| author | Salomon Merikansky Carolina Mercado Heather Durkee Rudolf Kobus Juan Carlos Navia Alejandro Arboleda Mariela C. Aguilar Jaime D. Martinez Harry W. Flynn Darlene Miller Jean-Marie Parel Guillermo Amescua |
| author_facet | Salomon Merikansky Carolina Mercado Heather Durkee Rudolf Kobus Juan Carlos Navia Alejandro Arboleda Mariela C. Aguilar Jaime D. Martinez Harry W. Flynn Darlene Miller Jean-Marie Parel Guillermo Amescua |
| author_sort | Salomon Merikansky |
| collection | DOAJ |
| description | Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to Pseudomonas aeruginosa. Methods Retrospective chart review was conducted on consecutive patients with scleritis and culture-proven Pseudomonas aeruginosa who underwent RB-PDAT. Results Six patients with Pseudomonas aeruginosa INS were included. All patients achieved complete resolution of the infection. The mean time to resolution after RB-PDAT was 17 days (range; 6–30 days), with a total treatment course average of 36 days (range; 22–60 days). One patient with pan-resistant Pseudomonas sclerokeratitis required two RB-PDAT treatments due to persistent stromal melting. All patients received a standardized regimen of oral fluoroquinolone, topical tobramycin, and ciprofloxacin/moxifloxacin. The patient with pan-resistant Pseudomonas aeruginosa required treatment with topical imipenem as well. None of the patients required enucleation. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by Pseudomonas aeruginosa, especially in cases of impending perforation. |
| format | Article |
| id | doaj-art-5f07331dced14b169dbee7f45b6de9a3 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-5f07331dced14b169dbee7f45b6de9a32025-08-20T02:27:35ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-06-015310457510.1016/j.pdpdt.2025.104575Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritisSalomon Merikansky0Carolina Mercado1Heather Durkee2Rudolf Kobus3Juan Carlos Navia4Alejandro Arboleda5Mariela C. Aguilar6Jaime D. Martinez7Harry W. Flynn8Darlene Miller9Jean-Marie Parel10Guillermo Amescua11Ocular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAAnne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Salvador Hospital, University of Chile, Santiago de Chile, ChileOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOcular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOcular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOphthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USAOcular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Anne Bates Leach Eye Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL, USA; Corresponding author at: Bascom Palmer Eye Institute, 900 NW 17th Street Miami, FL 33136, USA.Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to Pseudomonas aeruginosa. Methods Retrospective chart review was conducted on consecutive patients with scleritis and culture-proven Pseudomonas aeruginosa who underwent RB-PDAT. Results Six patients with Pseudomonas aeruginosa INS were included. All patients achieved complete resolution of the infection. The mean time to resolution after RB-PDAT was 17 days (range; 6–30 days), with a total treatment course average of 36 days (range; 22–60 days). One patient with pan-resistant Pseudomonas sclerokeratitis required two RB-PDAT treatments due to persistent stromal melting. All patients received a standardized regimen of oral fluoroquinolone, topical tobramycin, and ciprofloxacin/moxifloxacin. The patient with pan-resistant Pseudomonas aeruginosa required treatment with topical imipenem as well. None of the patients required enucleation. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by Pseudomonas aeruginosa, especially in cases of impending perforation.http://www.sciencedirect.com/science/article/pii/S1572100025001048Rose BengalNecrotizing scleritisPseudomonas aeruginosaPhotodynamic antimicrobial therapyScleraSurgical debridement |
| spellingShingle | Salomon Merikansky Carolina Mercado Heather Durkee Rudolf Kobus Juan Carlos Navia Alejandro Arboleda Mariela C. Aguilar Jaime D. Martinez Harry W. Flynn Darlene Miller Jean-Marie Parel Guillermo Amescua Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis Photodiagnosis and Photodynamic Therapy Rose Bengal Necrotizing scleritis Pseudomonas aeruginosa Photodynamic antimicrobial therapy Sclera Surgical debridement |
| title | Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis |
| title_full | Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis |
| title_fullStr | Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis |
| title_full_unstemmed | Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis |
| title_short | Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis |
| title_sort | rose bengal photodynamic antimicrobial therapy as an adjunct treatment for pseudomonas aeruginosa infectious necrotizing scleritis |
| topic | Rose Bengal Necrotizing scleritis Pseudomonas aeruginosa Photodynamic antimicrobial therapy Sclera Surgical debridement |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025001048 |
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