Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque)
<b>Background:</b> Cardiovascular disease is one of the leading causes of death around the globe. Atherosclerosis, a chronic inflammatory blood vessel disease that takes years to develop, is its primary cause. Instability and further plaque buildup are caused by chronic inflammation, whi...
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MDPI AG
2025-02-01
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| author | Piotr Wańczura Wiktoria Mytych Dorota Bartusik-Aebisher Dawid Leksa Adrian Truszkiewicz David Aebisher |
| author_facet | Piotr Wańczura Wiktoria Mytych Dorota Bartusik-Aebisher Dawid Leksa Adrian Truszkiewicz David Aebisher |
| author_sort | Piotr Wańczura |
| collection | DOAJ |
| description | <b>Background:</b> Cardiovascular disease is one of the leading causes of death around the globe. Atherosclerosis, a chronic inflammatory blood vessel disease that takes years to develop, is its primary cause. Instability and further plaque buildup are caused by chronic inflammation, which creates the conditions for possible rupture. The visualization of arterial lesions in situ can enhance understanding of atherosclerosis progression and potentially improve experimental therapies. Conventional histology methods for assessing atherosclerotic lesions are robust but are destructive and may prevent further tissue analysis. <b>Objectives:</b> The objective of the current study was to evaluate a novel, nondestructive method for the visualization and characterization of atherosclerotic lesions. <b>Methods and Results:</b> Thus, we tested the hypothesis that MRI paired with an iodine-based radiopaque stain would effectively characterize atherosclerotic plaques in a manner comparable to routine histology while maintaining sample integrity and providing whole-volume data. |
| format | Article |
| id | doaj-art-5f06a1a63c4d487c929b7b49225dcdf3 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-5f06a1a63c4d487c929b7b49225dcdf32025-08-20T03:12:16ZengMDPI AGBiomedicines2227-90592025-02-0113239910.3390/biomedicines13020399Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque)Piotr Wańczura0Wiktoria Mytych1Dorota Bartusik-Aebisher2Dawid Leksa3Adrian Truszkiewicz4David Aebisher5Department of Cardiology, Medical College of Sciences, The Rzeszów University, 35-310 Rzeszów, PolandEnglish Division Science Club, Medical College, The Rzeszów University, 35-310 Rzeszów, PolandDepartment of Biochemistry and General Chemistry, Medical College, The Rzeszów University, 35-310 Rzeszów, PolandRzeszów Center for Vascular and Endovascular Surgery, 35-310 Rzeszów, PolandDepartment of Photomedicine and Physical Chemistry, Medical College, The Rzeszów University, 35-310 Rzeszów, PolandDepartment of Photomedicine and Physical Chemistry, Medical College, The Rzeszów University, 35-310 Rzeszów, Poland<b>Background:</b> Cardiovascular disease is one of the leading causes of death around the globe. Atherosclerosis, a chronic inflammatory blood vessel disease that takes years to develop, is its primary cause. Instability and further plaque buildup are caused by chronic inflammation, which creates the conditions for possible rupture. The visualization of arterial lesions in situ can enhance understanding of atherosclerosis progression and potentially improve experimental therapies. Conventional histology methods for assessing atherosclerotic lesions are robust but are destructive and may prevent further tissue analysis. <b>Objectives:</b> The objective of the current study was to evaluate a novel, nondestructive method for the visualization and characterization of atherosclerotic lesions. <b>Methods and Results:</b> Thus, we tested the hypothesis that MRI paired with an iodine-based radiopaque stain would effectively characterize atherosclerotic plaques in a manner comparable to routine histology while maintaining sample integrity and providing whole-volume data.https://www.mdpi.com/2227-9059/13/2/399visualizationatherosclerotic plaquesMRIiodineatherosclerosis |
| spellingShingle | Piotr Wańczura Wiktoria Mytych Dorota Bartusik-Aebisher Dawid Leksa Adrian Truszkiewicz David Aebisher Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) Biomedicines visualization atherosclerotic plaques MRI iodine atherosclerosis |
| title | Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) |
| title_full | Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) |
| title_fullStr | Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) |
| title_full_unstemmed | Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) |
| title_short | Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque) |
| title_sort | visualization of atherosclerotic plaques paired with joheksol 350 omnipaque |
| topic | visualization atherosclerotic plaques MRI iodine atherosclerosis |
| url | https://www.mdpi.com/2227-9059/13/2/399 |
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