The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)
Interleukins (ILs)—which are important members of cytokines—consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, ad...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2054431 |
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| author | Payam Behzadi Aga Syed Sameer Saniya Nissar Mujeeb Zafar Banday Márió Gajdács Herney Andrés García-Perdomo Kulsum Akhtar Marina Pinheiro Peter Magnusson Meysam Sarshar Cecilia Ambrosi |
| author_facet | Payam Behzadi Aga Syed Sameer Saniya Nissar Mujeeb Zafar Banday Márió Gajdács Herney Andrés García-Perdomo Kulsum Akhtar Marina Pinheiro Peter Magnusson Meysam Sarshar Cecilia Ambrosi |
| author_sort | Payam Behzadi |
| collection | DOAJ |
| description | Interleukins (ILs)—which are important members of cytokines—consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members. |
| format | Article |
| id | doaj-art-5f047a59184445de987e600b41bbbbd2 |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5f047a59184445de987e600b41bbbbd22025-08-20T02:05:49ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/2054431The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)Payam Behzadi0Aga Syed Sameer1Saniya Nissar2Mujeeb Zafar Banday3Márió Gajdács4Herney Andrés García-Perdomo5Kulsum Akhtar6Marina Pinheiro7Peter Magnusson8Meysam Sarshar9Cecilia Ambrosi10Department of MicrobiologyMolecular Disease & Diagnosis DivisionMolecular Disease & Diagnosis DivisionMolecular Disease & Diagnosis DivisionDepartment of Oral Biology and Experimental Dental ResearchDivision of UrologyDepartment of Clinical BiochemistryDepartamento de Ciências QuímicasCardiology Research UnitResearch LaboratoriesIRCCS San Raffaele RomaInterleukins (ILs)—which are important members of cytokines—consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members.http://dx.doi.org/10.1155/2022/2054431 |
| spellingShingle | Payam Behzadi Aga Syed Sameer Saniya Nissar Mujeeb Zafar Banday Márió Gajdács Herney Andrés García-Perdomo Kulsum Akhtar Marina Pinheiro Peter Magnusson Meysam Sarshar Cecilia Ambrosi The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) Journal of Immunology Research |
| title | The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) |
| title_full | The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) |
| title_fullStr | The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) |
| title_full_unstemmed | The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) |
| title_short | The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs) |
| title_sort | interleukin 1 il 1 superfamily cytokines and their single nucleotide polymorphisms snps |
| url | http://dx.doi.org/10.1155/2022/2054431 |
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