Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes
Chitosan (CS) a chemical substance taken from the shells of sea creatures that has various uses in industry, farming, and medicine, for example in medical dressings. Its derivatives significantly inhibit two types of cancer cells: Madin Darby Canine Kidney MDCK and MCF-7. These derivatives include t...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624005551 |
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| author | Mohsin Omar Mohammed Hameed Madlool Mohammed Alkubaisi Nadia Qader Haj |
| author_facet | Mohsin Omar Mohammed Hameed Madlool Mohammed Alkubaisi Nadia Qader Haj |
| author_sort | Mohsin Omar Mohammed |
| collection | DOAJ |
| description | Chitosan (CS) a chemical substance taken from the shells of sea creatures that has various uses in industry, farming, and medicine, for example in medical dressings. Its derivatives significantly inhibit two types of cancer cells: Madin Darby Canine Kidney MDCK and MCF-7. These derivatives include thiosemicarbazones, heterocyclic moieties, and their metal (II) complexes. In this study, CS from crab shells is mixed with thiosemicarbazide (TSC). Then, imidazole-2-carboxaldehyde, oxazole-2-carboxaldehyde, and thiazole-2-carboxaldehyde reacted to make three different compounds from CS-TSC: [2a], [2b], and [2c]. The chemicals were mixed with nickel chloride to create nickel (II) chitosan 2-acetyl heterocyclic-2-thiosemicarbazone complexes. SEM and X-ray tests were performed on the powder, which showed that the nickel (II) chitosan thiosemicarbazone complexes had square and flat shapes. The synthesized compounds were tested to check their effectiveness in preventing MDCK and MCF-7. The study found that chitosan derivatives significantly inhibited MDCK and MCF-7. |
| format | Article |
| id | doaj-art-5efb9c6803cb4dafa35e853181da21f1 |
| institution | OA Journals |
| issn | 2211-7156 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-5efb9c6803cb4dafa35e853181da21f12025-08-20T02:39:02ZengElsevierResults in Chemistry2211-71562024-12-011210185910.1016/j.rechem.2024.101859Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexesMohsin Omar Mohammed0Hameed Madlool Mohammed Alkubaisi1Nadia Qader Haj2Chemistry Department, College of Science, University of Kirkuk, Iraq; Corresponding authors.Biotechnology and Environmental centre, University of Fallujah, IraqGeology Department, College of Science, University of Kirkuk, IraqChitosan (CS) a chemical substance taken from the shells of sea creatures that has various uses in industry, farming, and medicine, for example in medical dressings. Its derivatives significantly inhibit two types of cancer cells: Madin Darby Canine Kidney MDCK and MCF-7. These derivatives include thiosemicarbazones, heterocyclic moieties, and their metal (II) complexes. In this study, CS from crab shells is mixed with thiosemicarbazide (TSC). Then, imidazole-2-carboxaldehyde, oxazole-2-carboxaldehyde, and thiazole-2-carboxaldehyde reacted to make three different compounds from CS-TSC: [2a], [2b], and [2c]. The chemicals were mixed with nickel chloride to create nickel (II) chitosan 2-acetyl heterocyclic-2-thiosemicarbazone complexes. SEM and X-ray tests were performed on the powder, which showed that the nickel (II) chitosan thiosemicarbazone complexes had square and flat shapes. The synthesized compounds were tested to check their effectiveness in preventing MDCK and MCF-7. The study found that chitosan derivatives significantly inhibited MDCK and MCF-7.http://www.sciencedirect.com/science/article/pii/S2211715624005551ChitosanCancerComplexesThiosemicarbazonesHeterocyclic compounds |
| spellingShingle | Mohsin Omar Mohammed Hameed Madlool Mohammed Alkubaisi Nadia Qader Haj Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes Results in Chemistry Chitosan Cancer Complexes Thiosemicarbazones Heterocyclic compounds |
| title | Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes |
| title_full | Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes |
| title_fullStr | Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes |
| title_full_unstemmed | Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes |
| title_short | Synthesis, Identification, and anti-cancer Evaluation of Some heterocyclic Chitosan-Thiosemicarbazones compounds and their nickle (II) complexes |
| title_sort | synthesis identification and anti cancer evaluation of some heterocyclic chitosan thiosemicarbazones compounds and their nickle ii complexes |
| topic | Chitosan Cancer Complexes Thiosemicarbazones Heterocyclic compounds |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624005551 |
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