Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age
In recent years, examines the role of viral infection in the development of IgA-nephropathy. In our study, an analysis of renal biopsy tissue from 17 patients IgA-nephropathy in the presence of adenoviral antigen. Shown the presence of adenovirus infection in kidney tissue in patients with IgA-nephr...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/45 |
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| author | I. A. Rakityanskaya T. S. Ryabova |
| author_facet | I. A. Rakityanskaya T. S. Ryabova |
| author_sort | I. A. Rakityanskaya |
| collection | DOAJ |
| description | In recent years, examines the role of viral infection in the development of IgA-nephropathy. In our study, an analysis of renal biopsy tissue from 17 patients IgA-nephropathy in the presence of adenoviral antigen. Shown the presence of adenovirus infection in kidney tissue in patients with IgA-nephropathy, regardless of age: 52% of patients 60 years and 33% of patients older than 60 years. Revealed that the presence of adenovirus in the glomerular zone of influence on the severity of global sclerosis in both age groups (p <0.05) and in patients younger than 60 years the presence of adenovirus in the interstitium correlated with the severity of degeneration of the epithelium of tubules (p = 0.014). It also shows that the presence of adenovirus in the interstitium correlated with cell phenotype CD19 / λ (p = 0,004) and CD19 / κ (p = 0,002), intenstivnostyu expression of IL-10 (p = 0,029) and membranoatakuyuschego complex S5b-C9 (p = 0.011) in the glomerular zone in patients younger than 60 years. In patients older than 60 years, the influence of adenoviral infection of renal tissue to a local immune response have been identified. Based on these results, it is concluded that the presence of adenovirus infection in the kidney plays a role in the pathogenesis of IgA-nephropathy |
| format | Article |
| id | doaj-art-5efa550257a243d78be74b9ef5f931b1 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-5efa550257a243d78be74b9ef5f931b12025-08-20T04:00:07ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0133747810.22625/2072-6732-2011-3-3-74-7859Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to ageI. A. Rakityanskaya0T. S. Ryabova1Hospital of Holy Martyr George, Saint-PetersburgHospital of Holy Martyr George, Saint-PetersburgIn recent years, examines the role of viral infection in the development of IgA-nephropathy. In our study, an analysis of renal biopsy tissue from 17 patients IgA-nephropathy in the presence of adenoviral antigen. Shown the presence of adenovirus infection in kidney tissue in patients with IgA-nephropathy, regardless of age: 52% of patients 60 years and 33% of patients older than 60 years. Revealed that the presence of adenovirus in the glomerular zone of influence on the severity of global sclerosis in both age groups (p <0.05) and in patients younger than 60 years the presence of adenovirus in the interstitium correlated with the severity of degeneration of the epithelium of tubules (p = 0.014). It also shows that the presence of adenovirus in the interstitium correlated with cell phenotype CD19 / λ (p = 0,004) and CD19 / κ (p = 0,002), intenstivnostyu expression of IL-10 (p = 0,029) and membranoatakuyuschego complex S5b-C9 (p = 0.011) in the glomerular zone in patients younger than 60 years. In patients older than 60 years, the influence of adenoviral infection of renal tissue to a local immune response have been identified. Based on these results, it is concluded that the presence of adenovirus infection in the kidney plays a role in the pathogenesis of IgA-nephropathyhttps://journal.niidi.ru/jofin/article/view/45iga-nephropathyadenovirusmorphologyage |
| spellingShingle | I. A. Rakityanskaya T. S. Ryabova Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age Журнал инфектологии iga-nephropathy adenovirus morphology age |
| title | Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age |
| title_full | Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age |
| title_fullStr | Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age |
| title_full_unstemmed | Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age |
| title_short | Immuno-morphological aspects of the pathogenesis iga-nephropathy in patients with adenovirus infection with regard to age |
| title_sort | immuno morphological aspects of the pathogenesis iga nephropathy in patients with adenovirus infection with regard to age |
| topic | iga-nephropathy adenovirus morphology age |
| url | https://journal.niidi.ru/jofin/article/view/45 |
| work_keys_str_mv | AT iarakityanskaya immunomorphologicalaspectsofthepathogenesisiganephropathyinpatientswithadenovirusinfectionwithregardtoage AT tsryabova immunomorphologicalaspectsofthepathogenesisiganephropathyinpatientswithadenovirusinfectionwithregardtoage |