Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives
Objective: To analyze the research status and development prospects of hydrogels in the field of bone regeneration based on bibliometric methods. Methods: In the Web of Science Core Collection database, a total of 1382 representative articles related to the application of hydrogels in bone regenerat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000823 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849312110351220736 |
|---|---|
| author | Alimujiang Abudourousuli Aikebaierjiang Aisaiti Kan Jiang Shalayiding Aierxiding Kutiluke Shoukeer Ran Han Aikeremujiang Muheremu |
| author_facet | Alimujiang Abudourousuli Aikebaierjiang Aisaiti Kan Jiang Shalayiding Aierxiding Kutiluke Shoukeer Ran Han Aikeremujiang Muheremu |
| author_sort | Alimujiang Abudourousuli |
| collection | DOAJ |
| description | Objective: To analyze the research status and development prospects of hydrogels in the field of bone regeneration based on bibliometric methods. Methods: In the Web of Science Core Collection database, a total of 1382 representative articles related to the application of hydrogels in bone regeneration were selected as of the end of 2023. Utilizing the tools VOSviewer and CiteSpace, an in-depth bibliometric visualization analysis was conducted to reveal the countries, authors, core literature, and journals that are highly productive in this field. Additionally, the research trends and development prospects within this area were analyzed. Results: This study uses VOSviewer and CiteSpace to analyze 1382 highly cited articles on bone regeneration and materials science, revealing key trends and the evolution of the field. The United States, China, South Korea, Germany, the UK, and Japan are the leading countries in scientific output, with strong collaboration networks. Major research institutions, particularly in China and Japan, focus on hydrogels for bone regeneration. Top journals include International Journal of Biological Macromolecules and Acta Biomaterialia. Key authors include Timothy E. L. Douglas, known for developing mineralization-enhanced hydrogels, and Robert E. Guldberg, focused on growth factor delivery systems. The field has shifted from simple filling materials to multifunctional composites, with advancements in gene editing, signaling molecules, and bone regeneration drugs. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimizing biodegradability and biocompatibility. Multifunctional composite hydrogels are expected to become the go-to materials for clinical bone repair. Conclusion: Advancements in technology have transformed hydrogels from simple fillers to multifunctional composites, playing a crucial role in bone regeneration. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimized biodegradability and biocompatibility. These developments indicate hydrogels will become the preferred material for clinical bone defect repair, significantly enhancing bone tissue repair and regeneration. |
| format | Article |
| id | doaj-art-5ef86ec29b564f36932498f87cc587f4 |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-5ef86ec29b564f36932498f87cc587f42025-08-20T03:53:12ZengElsevierRegenerative Therapy2352-32042025-06-012958759910.1016/j.reth.2025.04.006Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectivesAlimujiang Abudourousuli0Aikebaierjiang Aisaiti1Kan Jiang2Shalayiding Aierxiding3Kutiluke Shoukeer4Ran Han5Aikeremujiang Muheremu6Orthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, ChinaOrthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, ChinaOrthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Corresponding author.Orthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, ChinaOrthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, ChinaDepartment of Pediatric Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Corresponding author.Orthopedic Research Center, Department of Orthopedics, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Key Laboratory of Orthopedic Regenerative Medicine of Xinjiang Medical University, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 86830001, China; Corresponding author.Objective: To analyze the research status and development prospects of hydrogels in the field of bone regeneration based on bibliometric methods. Methods: In the Web of Science Core Collection database, a total of 1382 representative articles related to the application of hydrogels in bone regeneration were selected as of the end of 2023. Utilizing the tools VOSviewer and CiteSpace, an in-depth bibliometric visualization analysis was conducted to reveal the countries, authors, core literature, and journals that are highly productive in this field. Additionally, the research trends and development prospects within this area were analyzed. Results: This study uses VOSviewer and CiteSpace to analyze 1382 highly cited articles on bone regeneration and materials science, revealing key trends and the evolution of the field. The United States, China, South Korea, Germany, the UK, and Japan are the leading countries in scientific output, with strong collaboration networks. Major research institutions, particularly in China and Japan, focus on hydrogels for bone regeneration. Top journals include International Journal of Biological Macromolecules and Acta Biomaterialia. Key authors include Timothy E. L. Douglas, known for developing mineralization-enhanced hydrogels, and Robert E. Guldberg, focused on growth factor delivery systems. The field has shifted from simple filling materials to multifunctional composites, with advancements in gene editing, signaling molecules, and bone regeneration drugs. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimizing biodegradability and biocompatibility. Multifunctional composite hydrogels are expected to become the go-to materials for clinical bone repair. Conclusion: Advancements in technology have transformed hydrogels from simple fillers to multifunctional composites, playing a crucial role in bone regeneration. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimized biodegradability and biocompatibility. These developments indicate hydrogels will become the preferred material for clinical bone defect repair, significantly enhancing bone tissue repair and regeneration.http://www.sciencedirect.com/science/article/pii/S2352320425000823Bone regenerationHydrogelsBibliometricsOrthopedicsTissue engineeringBiomaterials |
| spellingShingle | Alimujiang Abudourousuli Aikebaierjiang Aisaiti Kan Jiang Shalayiding Aierxiding Kutiluke Shoukeer Ran Han Aikeremujiang Muheremu Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives Regenerative Therapy Bone regeneration Hydrogels Bibliometrics Orthopedics Tissue engineering Biomaterials |
| title | Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives |
| title_full | Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives |
| title_fullStr | Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives |
| title_full_unstemmed | Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives |
| title_short | Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives |
| title_sort | bibliometric analysis of hydrogels in bone regeneration research trends and future perspectives |
| topic | Bone regeneration Hydrogels Bibliometrics Orthopedics Tissue engineering Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000823 |
| work_keys_str_mv | AT alimujiangabudourousuli bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT aikebaierjiangaisaiti bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT kanjiang bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT shalayidingaierxiding bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT kutilukeshoukeer bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT ranhan bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives AT aikeremujiangmuheremu bibliometricanalysisofhydrogelsinboneregenerationresearchtrendsandfutureperspectives |