Stress in Fish: Neuroendocrine and Neurotransmitter Responses

Farmed fish face persistent challenges arising from diverse environmental factors and human activities, which induce both acute and chronic stress responses, thereby increasing their susceptibility to diseases and mortality. Therefore, it is essential to comprehend the stressors and corresponding st...

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Main Authors: Mingzhe Yuan, Qian Fang, Weiqun Lu, Xubo Wang, Tianwei Hao, Cheong-Meng Chong, Shan Chen
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Fishes
Subjects:
Online Access:https://www.mdpi.com/2410-3888/10/7/307
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author Mingzhe Yuan
Qian Fang
Weiqun Lu
Xubo Wang
Tianwei Hao
Cheong-Meng Chong
Shan Chen
author_facet Mingzhe Yuan
Qian Fang
Weiqun Lu
Xubo Wang
Tianwei Hao
Cheong-Meng Chong
Shan Chen
author_sort Mingzhe Yuan
collection DOAJ
description Farmed fish face persistent challenges arising from diverse environmental factors and human activities, which induce both acute and chronic stress responses, thereby increasing their susceptibility to diseases and mortality. Therefore, it is essential to comprehend the stressors and corresponding stress responses in fish to recognize and mitigate harmful stress during aquaculture practices. In this review, we provide an overview of the various stressors present in aquaculture, along with the resultant alterations in neuroendocrine responses, including the brain–sympathetic–chromaffin cell (BSC) axis, hypothalamus–pituitary–interrenal (HPI) axis, and caudal neurosecretory system (CNSS), as well as neurotransmitter levels within the nervous system, experienced by fish under different types of stress. Fish possess well-developed nervous and endocrine systems that respond to stress, with complex communication networks among these systems demonstrating distributed collaboration. An understanding of the neuroendocrine and neurotransmitter responses to stress may enhance our comprehension of fish stress mechanisms and facilitate the development of an integrated dietary supplementation strategy and improve their resilience against the diverse stresses encountered in aquaculture.
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series Fishes
spelling doaj-art-5ef64b1360ed4250aec49a35d5f613b62025-08-20T02:45:38ZengMDPI AGFishes2410-38882025-06-0110730710.3390/fishes10070307Stress in Fish: Neuroendocrine and Neurotransmitter ResponsesMingzhe Yuan0Qian Fang1Weiqun Lu2Xubo Wang3Tianwei Hao4Cheong-Meng Chong5Shan Chen6Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, ChinaKey Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, ChinaNational Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, ChinaKey Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, ChinaDepartment of Civil and Environmental Engineering, Faculty of Science and Technology, University of Macau, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, ChinaKey Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo 315211, ChinaFarmed fish face persistent challenges arising from diverse environmental factors and human activities, which induce both acute and chronic stress responses, thereby increasing their susceptibility to diseases and mortality. Therefore, it is essential to comprehend the stressors and corresponding stress responses in fish to recognize and mitigate harmful stress during aquaculture practices. In this review, we provide an overview of the various stressors present in aquaculture, along with the resultant alterations in neuroendocrine responses, including the brain–sympathetic–chromaffin cell (BSC) axis, hypothalamus–pituitary–interrenal (HPI) axis, and caudal neurosecretory system (CNSS), as well as neurotransmitter levels within the nervous system, experienced by fish under different types of stress. Fish possess well-developed nervous and endocrine systems that respond to stress, with complex communication networks among these systems demonstrating distributed collaboration. An understanding of the neuroendocrine and neurotransmitter responses to stress may enhance our comprehension of fish stress mechanisms and facilitate the development of an integrated dietary supplementation strategy and improve their resilience against the diverse stresses encountered in aquaculture.https://www.mdpi.com/2410-3888/10/7/307stressaquacultureneural responsesneuroendocrine responsesfish
spellingShingle Mingzhe Yuan
Qian Fang
Weiqun Lu
Xubo Wang
Tianwei Hao
Cheong-Meng Chong
Shan Chen
Stress in Fish: Neuroendocrine and Neurotransmitter Responses
Fishes
stress
aquaculture
neural responses
neuroendocrine responses
fish
title Stress in Fish: Neuroendocrine and Neurotransmitter Responses
title_full Stress in Fish: Neuroendocrine and Neurotransmitter Responses
title_fullStr Stress in Fish: Neuroendocrine and Neurotransmitter Responses
title_full_unstemmed Stress in Fish: Neuroendocrine and Neurotransmitter Responses
title_short Stress in Fish: Neuroendocrine and Neurotransmitter Responses
title_sort stress in fish neuroendocrine and neurotransmitter responses
topic stress
aquaculture
neural responses
neuroendocrine responses
fish
url https://www.mdpi.com/2410-3888/10/7/307
work_keys_str_mv AT mingzheyuan stressinfishneuroendocrineandneurotransmitterresponses
AT qianfang stressinfishneuroendocrineandneurotransmitterresponses
AT weiqunlu stressinfishneuroendocrineandneurotransmitterresponses
AT xubowang stressinfishneuroendocrineandneurotransmitterresponses
AT tianweihao stressinfishneuroendocrineandneurotransmitterresponses
AT cheongmengchong stressinfishneuroendocrineandneurotransmitterresponses
AT shanchen stressinfishneuroendocrineandneurotransmitterresponses