Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model
The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/309493 |
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| _version_ | 1849412661899427840 |
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| author | Ken Yasukawa Yoshimasa Kasahara |
| author_facet | Ken Yasukawa Yoshimasa Kasahara |
| author_sort | Ken Yasukawa |
| collection | DOAJ |
| description | The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold. |
| format | Article |
| id | doaj-art-5eeb2eb49e7a4a22aacd5e65422bc22b |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-5eeb2eb49e7a4a22aacd5e65422bc22b2025-08-20T03:34:22ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/309493309493Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation ModelKen Yasukawa0Yoshimasa Kasahara1School of Pharmacy, Nihon University, Chiba 274-8555, JapanThe Yamagata Prefectural Institute of Public Health, Yamagata 990-0031, JapanThe major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.http://dx.doi.org/10.1155/2013/309493 |
| spellingShingle | Ken Yasukawa Yoshimasa Kasahara Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model International Journal of Inflammation |
| title | Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model |
| title_full | Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model |
| title_fullStr | Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model |
| title_full_unstemmed | Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model |
| title_short | Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model |
| title_sort | effects of flavonoids from french marigold florets of tagetes patula l on acute inflammation model |
| url | http://dx.doi.org/10.1155/2013/309493 |
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