SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing

SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing

ObjectiveThis study aimed to elucidate the functional role and molecular mechanisms of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) through integrative analysis of single-cell RNA sequencing (scRNA-seq) data.Materials and methodsCellular subpopulations with...

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Bibliographic Details
Main Authors: Mingyan Bao, Zhangui Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
SPINK1
OSCC
single-cell RNA sequencing
EGFR
JAK/STAT3 signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1585277/full
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