Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion
[Objective] To evaluate the safety and efficacy of ABO non-identical platelets with reduced plasma (ABO-NPRP) transfusion in patients with hematological diseases. [Methods] A retrospective analysis was conducted on 52 therapeutic doses of apheresis platelets with reduced plasma prepared at Chongqing...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-07-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.007&lang=en |
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| _version_ | 1849344208439083008 |
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| author | DIAO Ronghua RUAN Qianying BAI Lu ZHANG Hong WANG Zerong FU Lei WANG Shichun |
| author_facet | DIAO Ronghua RUAN Qianying BAI Lu ZHANG Hong WANG Zerong FU Lei WANG Shichun |
| author_sort | DIAO Ronghua |
| collection | DOAJ |
| description | [Objective] To evaluate the safety and efficacy of ABO non-identical platelets with reduced plasma (ABO-NPRP) transfusion in patients with hematological diseases. [Methods] A retrospective analysis was conducted on 52 therapeutic doses of apheresis platelets with reduced plasma prepared at Chongqing Blood Center of the Chinese People's Liberation Army. The transfusion efficacy (24 h CCI) and the transfusion adverse reactions of these apheresis platelets were also observed in 35 patients with hematological diseases in First Affiliated Hospital of Army Medical University. Comparisons were made with a control group consisting of patients who received only identical apheresis platelets during the same period. Meanwhile, the effect of ABO-NPRP on the subsequent platelet transfusion efficacy was observed. [Results] There was no statistically significant difference in PDW, MPV, and PLCR before and after the preparation of apheresis platelets with reduced plasma (P>0.05), while the difference in platelet count was statistically significant [(2.86±0.34)×1011 per therapeutic dose vs (2.46±0.28)×1011 per therapeutic dose, P<0.001]; there was no statistically significant difference in the 24 h CCI transfusion efficacy between conventional identical apheresis platelets and ABO-NPRP, with transfusion efficacy rates of 76.60% and 78.85%, respectively (P>0.05); there was no statistically significant difference in platelet transfusion efficacy between the group with ABO-NPRP and the group without ABO-NPRP (completely identical transfusion group), with transfusion efficacy rates of 77.78% and 75.25%, respectively (P>0.05). [Conclusion] ABO-NPRP transfusion is safe, effective, demonstrating comparable efficacy to conventional identical transfusion. It can serve as an important complementary strategy to optimize the utilization of blood resources. |
| format | Article |
| id | doaj-art-5ee6cd53039c4ca6ac86c673beecd715 |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-5ee6cd53039c4ca6ac86c673beecd7152025-08-20T03:42:44ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-07-0138790991410.13303/j.cjbt.issn.1004-549x.2025.07.0071004-549X(2025)7-0909-06Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusionDIAO Ronghua0RUAN Qianying1BAI Lu2ZHANG Hong3WANG Zerong4FU Lei5WANG Shichun6Department of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Clinical Laboratory, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, ChinaDepartment of Blood Transfusion, First Affiliated Hospital of Army Medical University, Chongqing 400038, China[Objective] To evaluate the safety and efficacy of ABO non-identical platelets with reduced plasma (ABO-NPRP) transfusion in patients with hematological diseases. [Methods] A retrospective analysis was conducted on 52 therapeutic doses of apheresis platelets with reduced plasma prepared at Chongqing Blood Center of the Chinese People's Liberation Army. The transfusion efficacy (24 h CCI) and the transfusion adverse reactions of these apheresis platelets were also observed in 35 patients with hematological diseases in First Affiliated Hospital of Army Medical University. Comparisons were made with a control group consisting of patients who received only identical apheresis platelets during the same period. Meanwhile, the effect of ABO-NPRP on the subsequent platelet transfusion efficacy was observed. [Results] There was no statistically significant difference in PDW, MPV, and PLCR before and after the preparation of apheresis platelets with reduced plasma (P>0.05), while the difference in platelet count was statistically significant [(2.86±0.34)×1011 per therapeutic dose vs (2.46±0.28)×1011 per therapeutic dose, P<0.001]; there was no statistically significant difference in the 24 h CCI transfusion efficacy between conventional identical apheresis platelets and ABO-NPRP, with transfusion efficacy rates of 76.60% and 78.85%, respectively (P>0.05); there was no statistically significant difference in platelet transfusion efficacy between the group with ABO-NPRP and the group without ABO-NPRP (completely identical transfusion group), with transfusion efficacy rates of 77.78% and 75.25%, respectively (P>0.05). [Conclusion] ABO-NPRP transfusion is safe, effective, demonstrating comparable efficacy to conventional identical transfusion. It can serve as an important complementary strategy to optimize the utilization of blood resources.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.007&lang=enabo blood groupnon-identical plateletsnon-identical platelets with reduced plasmaplatelet transfusiontransfusion efficacy |
| spellingShingle | DIAO Ronghua RUAN Qianying BAI Lu ZHANG Hong WANG Zerong FU Lei WANG Shichun Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion Zhongguo shuxue zazhi abo blood group non-identical platelets non-identical platelets with reduced plasma platelet transfusion transfusion efficacy |
| title | Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion |
| title_full | Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion |
| title_fullStr | Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion |
| title_full_unstemmed | Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion |
| title_short | Evaluation of the safety and efficacy of ABO non-identical apheresis platelets with reduced plasma transfusion |
| title_sort | evaluation of the safety and efficacy of abo non identical apheresis platelets with reduced plasma transfusion |
| topic | abo blood group non-identical platelets non-identical platelets with reduced plasma platelet transfusion transfusion efficacy |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.07.007&lang=en |
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