SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis

SKAP1 Expression in Cancer Cells Enhances Colon Tumor Growth and Impairs Cytotoxic Immunity by Promoting Neutrophil Extracellular Trap Formation via the NFATc1/CXCL8 Axis

Abstract The mechanisms underlying the development and progression of colon cancer are not fully understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell adaptor, is identified as a novel colon cancer‐related gene. SKAP1 expression is significantly increased in colon cancer...

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Bibliographic Details
Main Authors: Jian Gao, Jun Liu, Jilin Lu, Xiaofei Zhang, Wei Zhang, Qian Li, Jiayi Cai, Mengjun Li, Yu Gan, Yifan Tang, Shuangjie Wu
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
colon cancer
CXCL8
neutrophil extracellular trap
NFATc1
SKAP1
Online Access:https://doi.org/10.1002/advs.202403430
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