Triple pathology in a patient with uncontrolled epilepsy: a case report
Abstract Background Sturge–Weber syndrome is an uncommon neurocutaneous disorder with characteristic vascular lesions, leptomeningeal angiomas, and facial nevi. Seizureis the most prevalent neurological sign of Sturge–Weber syndrome and complications related to seizure control, comorbidities, or out...
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BMC
2025-03-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-025-05137-x |
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| author | Sara Ranji Behnam Akbari Melika Javani Aidin Taghilou Abbas Tafakhori Saeideh Salehizadeh Hoda Naghshineh |
| author_facet | Sara Ranji Behnam Akbari Melika Javani Aidin Taghilou Abbas Tafakhori Saeideh Salehizadeh Hoda Naghshineh |
| author_sort | Sara Ranji |
| collection | DOAJ |
| description | Abstract Background Sturge–Weber syndrome is an uncommon neurocutaneous disorder with characteristic vascular lesions, leptomeningeal angiomas, and facial nevi. Seizureis the most prevalent neurological sign of Sturge–Weber syndrome and complications related to seizure control, comorbidities, or outcome can make the way of medical care turbid. Accordingly, the co-occurrence of Sturge–Weber syndrome with mesial temporal lobe sclerosis/mesial temporal sclerosis and low-grade glioma has not been reported in literature. Case report In this report, we present a 29-year-old Kurdish male with Sturge–Weber syndrome showing evidence of sclerotic changes in the medial part of the right temporal including the hippocampus in magnetic resonance imaging, in addition to a low-grade glioma. He used to have seizures, starting with left dominant somatosensory aura, before puberty. Interestingly, the semiology has changed to an epigastric aura afterward. Therefore, we assumed that there could be a new seizure onset zone. Seizures from the right mesial temporal region were recorded during long-term electroencephalogram monitoring admission. This finding was compatible with lesions found in the right temporal lobe. Conclusion Debates arise whether the co-occurrence of mesial temporal sclerosis and low-grade glioma with Sturge–Weber syndrome lesions is incidental or secondary to Sturge–Weber syndrome pathogenesis. Furthermore, this association can be attributed to a common genetic underlying. While there is no compelling evidence in this case to address the exact pathogenicity, the impact of early diagnosis and intense control of primary seizures on preventing downstream effects, such as sclerosis and tumor formations, is considerable. We strongly believe further research is needed to address this concern. |
| format | Article |
| id | doaj-art-5edc1957886543ef871a31d0c8e08cd7 |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-5edc1957886543ef871a31d0c8e08cd72025-08-20T03:40:48ZengBMCJournal of Medical Case Reports1752-19472025-03-011911510.1186/s13256-025-05137-xTriple pathology in a patient with uncontrolled epilepsy: a case reportSara Ranji0Behnam Akbari1Melika Javani2Aidin Taghilou3Abbas Tafakhori4Saeideh Salehizadeh5Hoda Naghshineh6Department of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesDepartment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesDepartment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesTehran University of Medical SciencesDepartment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesEpilepsy Center, Neurological Institute, University Hospitals, Cleveland Medical CenterDepartment of Neurology, Imam Khomeini Hospital Complex, Tehran University of Medical SciencesAbstract Background Sturge–Weber syndrome is an uncommon neurocutaneous disorder with characteristic vascular lesions, leptomeningeal angiomas, and facial nevi. Seizureis the most prevalent neurological sign of Sturge–Weber syndrome and complications related to seizure control, comorbidities, or outcome can make the way of medical care turbid. Accordingly, the co-occurrence of Sturge–Weber syndrome with mesial temporal lobe sclerosis/mesial temporal sclerosis and low-grade glioma has not been reported in literature. Case report In this report, we present a 29-year-old Kurdish male with Sturge–Weber syndrome showing evidence of sclerotic changes in the medial part of the right temporal including the hippocampus in magnetic resonance imaging, in addition to a low-grade glioma. He used to have seizures, starting with left dominant somatosensory aura, before puberty. Interestingly, the semiology has changed to an epigastric aura afterward. Therefore, we assumed that there could be a new seizure onset zone. Seizures from the right mesial temporal region were recorded during long-term electroencephalogram monitoring admission. This finding was compatible with lesions found in the right temporal lobe. Conclusion Debates arise whether the co-occurrence of mesial temporal sclerosis and low-grade glioma with Sturge–Weber syndrome lesions is incidental or secondary to Sturge–Weber syndrome pathogenesis. Furthermore, this association can be attributed to a common genetic underlying. While there is no compelling evidence in this case to address the exact pathogenicity, the impact of early diagnosis and intense control of primary seizures on preventing downstream effects, such as sclerosis and tumor formations, is considerable. We strongly believe further research is needed to address this concern.https://doi.org/10.1186/s13256-025-05137-xEpilepsySturge–Weber syndromeLow-grade gliomaMesial temporal lobe sclerosisCase reportMesial temporal lobe epilepsy |
| spellingShingle | Sara Ranji Behnam Akbari Melika Javani Aidin Taghilou Abbas Tafakhori Saeideh Salehizadeh Hoda Naghshineh Triple pathology in a patient with uncontrolled epilepsy: a case report Journal of Medical Case Reports Epilepsy Sturge–Weber syndrome Low-grade glioma Mesial temporal lobe sclerosis Case report Mesial temporal lobe epilepsy |
| title | Triple pathology in a patient with uncontrolled epilepsy: a case report |
| title_full | Triple pathology in a patient with uncontrolled epilepsy: a case report |
| title_fullStr | Triple pathology in a patient with uncontrolled epilepsy: a case report |
| title_full_unstemmed | Triple pathology in a patient with uncontrolled epilepsy: a case report |
| title_short | Triple pathology in a patient with uncontrolled epilepsy: a case report |
| title_sort | triple pathology in a patient with uncontrolled epilepsy a case report |
| topic | Epilepsy Sturge–Weber syndrome Low-grade glioma Mesial temporal lobe sclerosis Case report Mesial temporal lobe epilepsy |
| url | https://doi.org/10.1186/s13256-025-05137-x |
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