Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds
In recent years, amino-<i>gem</i>-bisphosphonic acids and their esters have been considered a family of compounds of great chemical and pharmacological interest due to their important biological properties and their value as key synthons in the synthesis of more complex molecules with bi...
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MDPI AG
2025-07-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/18/7/1063 |
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| author | Mario Ordoñez Rubén Oswaldo Argüello Velasco |
| author_facet | Mario Ordoñez Rubén Oswaldo Argüello Velasco |
| author_sort | Mario Ordoñez |
| collection | DOAJ |
| description | In recent years, amino-<i>gem</i>-bisphosphonic acids and their esters have been considered a family of compounds of great chemical and pharmacological interest due to their important biological properties and their value as key synthons in the synthesis of more complex molecules with biological interest. This explains why several research groups are interested in developing new methods for the preparation of these compounds. Therefore, we would like to report here a summary of the synthetic strategies published in the last fifteen years for the synthesis of acyclic and heterocyclic α-, β- and γ-amino-gem-bisphosphonates, as well as their application in the preparation of selected compounds of chemical and pharmacological interest. This information can be of general knowledge to researchers working in this area, as it provides the starting point for new methods and applications of these compounds. |
| format | Article |
| id | doaj-art-5edb3229e62a41a998ebc6b4753a13eb |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-5edb3229e62a41a998ebc6b4753a13eb2025-08-20T03:56:46ZengMDPI AGPharmaceuticals1424-82472025-07-01187106310.3390/ph18071063Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant CompoundsMario Ordoñez0Rubén Oswaldo Argüello Velasco1Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Morelos, MexicoFacultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Morelos, MexicoIn recent years, amino-<i>gem</i>-bisphosphonic acids and their esters have been considered a family of compounds of great chemical and pharmacological interest due to their important biological properties and their value as key synthons in the synthesis of more complex molecules with biological interest. This explains why several research groups are interested in developing new methods for the preparation of these compounds. Therefore, we would like to report here a summary of the synthetic strategies published in the last fifteen years for the synthesis of acyclic and heterocyclic α-, β- and γ-amino-gem-bisphosphonates, as well as their application in the preparation of selected compounds of chemical and pharmacological interest. This information can be of general knowledge to researchers working in this area, as it provides the starting point for new methods and applications of these compounds.https://www.mdpi.com/1424-8247/18/7/1063synthesis of amino-<i>gem</i>-bisphosphonatessynthesis of amino-<i>gem</i>-bisphosphonic acidsbiological activity of amino-<i>gem</i>-bisphosphonates |
| spellingShingle | Mario Ordoñez Rubén Oswaldo Argüello Velasco Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds Pharmaceuticals synthesis of amino-<i>gem</i>-bisphosphonates synthesis of amino-<i>gem</i>-bisphosphonic acids biological activity of amino-<i>gem</i>-bisphosphonates |
| title | Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds |
| title_full | Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds |
| title_fullStr | Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds |
| title_full_unstemmed | Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds |
| title_short | Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds |
| title_sort | synthesis of amino i gem i bisphosphonate derivatives and their application as synthons for the preparation of biorelevant compounds |
| topic | synthesis of amino-<i>gem</i>-bisphosphonates synthesis of amino-<i>gem</i>-bisphosphonic acids biological activity of amino-<i>gem</i>-bisphosphonates |
| url | https://www.mdpi.com/1424-8247/18/7/1063 |
| work_keys_str_mv | AT marioordonez synthesisofaminoigemibisphosphonatederivativesandtheirapplicationassynthonsforthepreparationofbiorelevantcompounds AT rubenoswaldoarguellovelasco synthesisofaminoigemibisphosphonatederivativesandtheirapplicationassynthonsforthepreparationofbiorelevantcompounds |