Development and Validation of Salbutamol, Bromhexine, Ambroxol and Guauaifenesin Determination in Human Plasma by HPLC-MS/MS Method

Development and Validation of Salbutamol, Bromhexine, Ambroxol and Guauaifenesin Determination in Human Plasma by HPLC-MS/MS Method

Introduction. Multicomponent oral drugs containing salbutamol, bromhexine, ambroxol and guaifenesin have a mucolytic, expectorant and bronchodilator effect. The development method for determination substances in biological fluids is a main procedure for performing the analytical part of pharmacokine...

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Bibliographic Details
Main Authors: T. N. Komarov, D. S. Bogdanova, O. A. Miskiv, A. V. Aleshina, I. E. Shohin, Yu. V. Medvedev, N. S. Bagaeva, I. M. Korenskaya
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-11-01
Series:Разработка и регистрация лекарственных средств
Subjects:
salbutamol
bromhexine
ambroxol
guaifenesin
plasma
hplc-ms/ms
determination
validation
Online Access:https://www.pharmjournal.ru/jour/article/view/739
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