Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021
Objective: To identify any differences in the characteristics and outcomes of patients with Isolated cardiac sarcoidosis (iCS) vs systemic cardiac sarcoidosis (sCS). Patients and methods: All inpatient encounters in the Nationwide Readmission Database from 2016 to 2021 were analyzed for the rates, p...
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Elsevier
2025-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000399 |
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| author | Raheel Ahmed Nitish Behary Paray Hiroyuki Sawatari Syed Emir Irfan Wafa Kamleshun Ramphul Mushood Ahmed Hritvik Jain Saurabh Deshpande Mohammed Khanji Athol Umfrey Wells Peter Collins Selma Mohammed Omar Abou-Ezzeddine Vasilis Kouranos Rakesh Sharma Anwar Chahal |
| author_facet | Raheel Ahmed Nitish Behary Paray Hiroyuki Sawatari Syed Emir Irfan Wafa Kamleshun Ramphul Mushood Ahmed Hritvik Jain Saurabh Deshpande Mohammed Khanji Athol Umfrey Wells Peter Collins Selma Mohammed Omar Abou-Ezzeddine Vasilis Kouranos Rakesh Sharma Anwar Chahal |
| author_sort | Raheel Ahmed |
| collection | DOAJ |
| description | Objective: To identify any differences in the characteristics and outcomes of patients with Isolated cardiac sarcoidosis (iCS) vs systemic cardiac sarcoidosis (sCS). Patients and methods: All inpatient encounters in the Nationwide Readmission Database from 2016 to 2021 were analyzed for the rates, predictors, costs and mortality during index and unplanned 90-days readmissions for iCS and sCS patients. Patients with ischemic heart disease were excluded. Results: 1,667 patients were identified (57.8 % male), of which, 1,013 (60.8 %) had iCS and 654 (39.2 %) had sCS. The median (IQR) age of iCS patients was slightly older [57.0 (49.0–66.0) vs 56.0 (48.0–64.0), p = 0.04]. On index admission, iCS patients had higher prevalence of ventricular tachycardia (36.9 % vs 28.8 %, p = 0.001) and catheter ablation (5.6 % vs 2.8 %, p = 0.006). The predictors for all-cause readmissions were Charlson Comorbidity Index (CCI) (HR 1.19, 95 % CI 1.01–1.40, p = 0.04), age (HR 0.98 (0.97–1.00), p = 0.01) and the use of anticoagulant therapy (HR 1.92, 95 % CI 1.35–2.72, p < 0.001). Patients with sCS were more likely to be readmitted with heart failure compared to iCS patients (SHR 3.78, 95 % CI 1.11–12.94, p = 0.03). During subsequent readmission, iCS and sCS patients had comparable rates of in-hospital mortality, median length of stay and healthcare-associated costs. No independent predictors of in-hospital mortality at readmission were ascertained. Conclusions: Isolated CS patients, when compared to systemic CS, had a greater prevalence of ventricular tachycardia and catheter ablation. They were less likely to be re-hospitalized with heart failure within 90-days. Age, higher CCI, and use of anticoagulant therapy were predictors for all-cause readmissions. |
| format | Article |
| id | doaj-art-5ed31eba88154a1c82e968e86b7f0eb3 |
| institution | OA Journals |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-5ed31eba88154a1c82e968e86b7f0eb32025-08-20T02:04:11ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-04-015710163610.1016/j.ijcha.2025.101636Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021Raheel Ahmed0Nitish Behary Paray1Hiroyuki Sawatari2Syed Emir Irfan Wafa3Kamleshun Ramphul4Mushood Ahmed5Hritvik Jain6Saurabh Deshpande7Mohammed Khanji8Athol Umfrey Wells9Peter Collins10Selma Mohammed11Omar Abou-Ezzeddine12Vasilis Kouranos13Rakesh Sharma14Anwar Chahal15Cardiac Sarcoidosis Services, Royal Brompton Hospital, Part of Guy’s and St Thomas’ NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Corresponding author at: Department of Cardiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, United Kingdom.Royal Devon University Healthcare NHS Foundation Trust, Exeter, United KingdomGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanRussell’s Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, United KingdomIndependent Researcher, MauritiusRawalpindi Medical University, Rawalpindi, PakistanDepartment of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur, IndiaDepartment of Electrophysiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, IndiaWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom; Newham University Hospital, Barts Health NHS Trust, Glen Road, London E13 8SL, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, United KingdomCardiac Sarcoidosis Services, Royal Brompton Hospital, Part of Guy’s and St Thomas’ NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United KingdomCardiac Sarcoidosis Services, Royal Brompton Hospital, Part of Guy’s and St Thomas’ NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United KingdomDepartment of Cardiology, Creighton University, Omaha, USADepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Str, SW Rochester, MN 55905, USACardiac Sarcoidosis Services, Royal Brompton Hospital, Part of Guy’s and St Thomas’ NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United KingdomCardiac Sarcoidosis Services, Royal Brompton Hospital, Part of Guy’s and St Thomas’ NHS Trust, London, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Kings College London, London, United KingdomWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, United Kingdom; Department of Cardiovascular Medicine, Mayo Clinic, 200 First Str, SW Rochester, MN 55905, USA; Center for Inherited Cardiovascular Diseases, Department of Cardiology, WellSpan Health, 30 Monument Rd, York, PA 17403, USAObjective: To identify any differences in the characteristics and outcomes of patients with Isolated cardiac sarcoidosis (iCS) vs systemic cardiac sarcoidosis (sCS). Patients and methods: All inpatient encounters in the Nationwide Readmission Database from 2016 to 2021 were analyzed for the rates, predictors, costs and mortality during index and unplanned 90-days readmissions for iCS and sCS patients. Patients with ischemic heart disease were excluded. Results: 1,667 patients were identified (57.8 % male), of which, 1,013 (60.8 %) had iCS and 654 (39.2 %) had sCS. The median (IQR) age of iCS patients was slightly older [57.0 (49.0–66.0) vs 56.0 (48.0–64.0), p = 0.04]. On index admission, iCS patients had higher prevalence of ventricular tachycardia (36.9 % vs 28.8 %, p = 0.001) and catheter ablation (5.6 % vs 2.8 %, p = 0.006). The predictors for all-cause readmissions were Charlson Comorbidity Index (CCI) (HR 1.19, 95 % CI 1.01–1.40, p = 0.04), age (HR 0.98 (0.97–1.00), p = 0.01) and the use of anticoagulant therapy (HR 1.92, 95 % CI 1.35–2.72, p < 0.001). Patients with sCS were more likely to be readmitted with heart failure compared to iCS patients (SHR 3.78, 95 % CI 1.11–12.94, p = 0.03). During subsequent readmission, iCS and sCS patients had comparable rates of in-hospital mortality, median length of stay and healthcare-associated costs. No independent predictors of in-hospital mortality at readmission were ascertained. Conclusions: Isolated CS patients, when compared to systemic CS, had a greater prevalence of ventricular tachycardia and catheter ablation. They were less likely to be re-hospitalized with heart failure within 90-days. Age, higher CCI, and use of anticoagulant therapy were predictors for all-cause readmissions.http://www.sciencedirect.com/science/article/pii/S2352906725000399Isolated cardiac sarcoidosisSystemic sarcoidosisNational Readmissions Database |
| spellingShingle | Raheel Ahmed Nitish Behary Paray Hiroyuki Sawatari Syed Emir Irfan Wafa Kamleshun Ramphul Mushood Ahmed Hritvik Jain Saurabh Deshpande Mohammed Khanji Athol Umfrey Wells Peter Collins Selma Mohammed Omar Abou-Ezzeddine Vasilis Kouranos Rakesh Sharma Anwar Chahal Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 International Journal of Cardiology: Heart & Vasculature Isolated cardiac sarcoidosis Systemic sarcoidosis National Readmissions Database |
| title | Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 |
| title_full | Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 |
| title_fullStr | Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 |
| title_full_unstemmed | Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 |
| title_short | Characteristics and outcomes of hospitalized patients with Isolated and systemic cardiac sarcoidosis: Analysis of the Nationwide readmissions database 2016–2021 |
| title_sort | characteristics and outcomes of hospitalized patients with isolated and systemic cardiac sarcoidosis analysis of the nationwide readmissions database 2016 2021 |
| topic | Isolated cardiac sarcoidosis Systemic sarcoidosis National Readmissions Database |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000399 |
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