Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma
Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLeva...
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| Format: | Article |
| Language: | Russian |
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2018-03-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/60 |
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| author | M. A. Yarkova A. A. Litvin G. B. Kolyvanov V. P. Zherdev S. B. Seredenin V. I. Gegechkori |
| author_facet | M. A. Yarkova A. A. Litvin G. B. Kolyvanov V. P. Zherdev S. B. Seredenin V. I. Gegechkori |
| author_sort | M. A. Yarkova |
| collection | DOAJ |
| description | Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLevated pLus maze” were evaLuated. A vaLue of GML-1 anxioLytic effect does not correLate to concentration in the rat bLood pLasma. |
| format | Article |
| id | doaj-art-5ecfaaae51754e8db8b29e3bfd446b89 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2018-03-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-5ecfaaae51754e8db8b29e3bfd446b892025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302018-03-0102525810.24411/25877836-2018-10014.59Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasmaM. A. Yarkova0A. A. Litvin1G. B. Kolyvanov2V. P. Zherdev3S. B. Seredenin4V. I. Gegechkori5FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSAEI HE I.M. Sechenov First MSMU MOH Russia (Sechenovskiy University)Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLevated pLus maze” were evaLuated. A vaLue of GML-1 anxioLytic effect does not correLate to concentration in the rat bLood pLasma.https://www.pharmacokinetica.ru/jour/article/view/60лиганд tspoгмл-1корреляция «эффект-концентрация»ligand of tspogml-1“effect-concentration” correlation |
| spellingShingle | M. A. Yarkova A. A. Litvin G. B. Kolyvanov V. P. Zherdev S. B. Seredenin V. I. Gegechkori Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma Фармакокинетика и Фармакодинамика лиганд tspo гмл-1 корреляция «эффект-концентрация» ligand of tspo gml-1 “effect-concentration” correlation |
| title | Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma |
| title_full | Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma |
| title_fullStr | Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma |
| title_full_unstemmed | Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma |
| title_short | Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma |
| title_sort | search of the correlation berween anxiolytic effect of original derivative of pyrrolo 1 2 a pyrazine tspo ligand gml 1 and its concentrations in the rat blood plasma |
| topic | лиганд tspo гмл-1 корреляция «эффект-концентрация» ligand of tspo gml-1 “effect-concentration” correlation |
| url | https://www.pharmacokinetica.ru/jour/article/view/60 |
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