Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway

Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway

To date, no specific treatments have been developed for high-salt-induced hypertensive vascular damage, emphasizing the need to elucidate its underlying molecular mechanisms for therapeutic innovation. Kaempferol (Kae), a natural flavonol belonging to the flavonoid family, has demonstrated significa...

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Bibliographic Details
Main Authors: Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Functional Foods
Subjects:
High-salt-induced hypertension
Kaempferol
Ferroptosis
ATF4/ACSL4 pathway
Vascular endothelial injury
Online Access:http://www.sciencedirect.com/science/article/pii/S175646462500026X
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