Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer
Prostate cancer (PCa) is recognized as a common malignancy in male patients. The homeobox A cluster (HOXA) family members have been confirmed to be implicated in the development of several types of tumors. However, the expression pattern and prognostic values of HOXA genes in PCa have not been inves...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5740971 |
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| author | Yan-ping Song Peng Xian Hong Luo Jun-yong Dai Yu Bai Yuan Li Xian-li Tang |
| author_facet | Yan-ping Song Peng Xian Hong Luo Jun-yong Dai Yu Bai Yuan Li Xian-li Tang |
| author_sort | Yan-ping Song |
| collection | DOAJ |
| description | Prostate cancer (PCa) is recognized as a common malignancy in male patients. The homeobox A cluster (HOXA) family members have been confirmed to be implicated in the development of several types of tumors. However, the expression pattern and prognostic values of HOXA genes in PCa have not been investigated. In this study, we analyzed TCGA datasets and identified six HOXA family members which showed a dysregulated expression in PCa specimens compared with nontumor specimens. We also explored the potential mechanisms involved in the dysregulation of HOXA family members in PCa, and the results of Pearson’s correlation revealed that most HOXA members were negatively related to the methylation degree. Moreover, we explored the prognostic values of HOXA family members and identified six survival-related HOXA members. Importantly, HOXA2, HOXA9, and HOXA10 were identified as critical PCa-related genes which were abnormally expressed in PCa and associated with clinical outcomes of PCa patients. Then, we explored the association between the above three genes and immune cell infiltration. We observed that the levels of HOXA2, HOXA9, and HOXA10 were associated with the levels of immune infiltration of several kinds of immune cells. Overall, our findings identified the potential values of the HOXA family for outcome prediction in PCa, which might facilitate personalized counselling and treatment in PCa. |
| format | Article |
| id | doaj-art-5ece74b1858b4ec18111165290f7e0bf |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5ece74b1858b4ec18111165290f7e0bf2025-08-20T03:34:33ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5740971Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate CancerYan-ping Song0Peng Xian1Hong Luo2Jun-yong Dai3Yu Bai4Yuan Li5Xian-li Tang6Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized TreatmentProstate cancer (PCa) is recognized as a common malignancy in male patients. The homeobox A cluster (HOXA) family members have been confirmed to be implicated in the development of several types of tumors. However, the expression pattern and prognostic values of HOXA genes in PCa have not been investigated. In this study, we analyzed TCGA datasets and identified six HOXA family members which showed a dysregulated expression in PCa specimens compared with nontumor specimens. We also explored the potential mechanisms involved in the dysregulation of HOXA family members in PCa, and the results of Pearson’s correlation revealed that most HOXA members were negatively related to the methylation degree. Moreover, we explored the prognostic values of HOXA family members and identified six survival-related HOXA members. Importantly, HOXA2, HOXA9, and HOXA10 were identified as critical PCa-related genes which were abnormally expressed in PCa and associated with clinical outcomes of PCa patients. Then, we explored the association between the above three genes and immune cell infiltration. We observed that the levels of HOXA2, HOXA9, and HOXA10 were associated with the levels of immune infiltration of several kinds of immune cells. Overall, our findings identified the potential values of the HOXA family for outcome prediction in PCa, which might facilitate personalized counselling and treatment in PCa.http://dx.doi.org/10.1155/2022/5740971 |
| spellingShingle | Yan-ping Song Peng Xian Hong Luo Jun-yong Dai Yu Bai Yuan Li Xian-li Tang Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer Journal of Immunology Research |
| title | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer |
| title_full | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer |
| title_fullStr | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer |
| title_full_unstemmed | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer |
| title_short | Comprehensive Landscape of HOXA2, HOXA9, and HOXA10 as Potential Biomarkers for Predicting Progression and Prognosis in Prostate Cancer |
| title_sort | comprehensive landscape of hoxa2 hoxa9 and hoxa10 as potential biomarkers for predicting progression and prognosis in prostate cancer |
| url | http://dx.doi.org/10.1155/2022/5740971 |
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