Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy
Prostate cancer (PCa) is a major cause of cancer-related deaths worldwide. While current treatments such as surveillance, surgery, and radiation are effective, they have their limitations. These can include patient incompliance due to side effects or resistance to hormonal changes, highlighting the...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Current Research in Microbial Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000823 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850113335985438720 |
|---|---|
| author | Rasoul Ebrahimi Shahrzad Shahrokhi Nejad Mehra Fekri Seyed Aria Nejadghaderi |
| author_facet | Rasoul Ebrahimi Shahrzad Shahrokhi Nejad Mehra Fekri Seyed Aria Nejadghaderi |
| author_sort | Rasoul Ebrahimi |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a major cause of cancer-related deaths worldwide. While current treatments such as surveillance, surgery, and radiation are effective, they have their limitations. These can include patient incompliance due to side effects or resistance to hormonal changes, highlighting the need for alternative approaches. Human microbiota, a complex and dynamic host, plays a significant role in the homeostasis and is associated with several diseases or cancers in cases of dysregulation and dysbiosis. Research on fecal microbiota profiling and its association with certain cancers has opened new possibilities for preventing and managing tumor progression. One such possibility is fecal microbial transplantation (FMT). Studies show that different composition of urinary microbiota is found in various urinary tract diseases. Gut microbiota can regulate immune response against tumors; therefore, FMT may help modulate gut microbiota in a way that potentially enhances responses to immune checkpoint inhibitors, as suggested by emerging evidence in other cancers, though this needs further validation in PCa. Nevertheless, long-term complications and the safety of FMT are still questioned. We reviewed the roles of gut microbiota in PCa and suggested FMT as a potential tool in the treatment of PCa, which needs further investigations. |
| format | Article |
| id | doaj-art-5ece559c46864576b19cfd59b77c5e83 |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-5ece559c46864576b19cfd59b77c5e832025-08-20T02:37:10ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-01910042010.1016/j.crmicr.2025.100420Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapyRasoul Ebrahimi0Shahrzad Shahrokhi Nejad1Mehra Fekri2Seyed Aria Nejadghaderi3School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranHIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran; Corresponding author at: HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.Prostate cancer (PCa) is a major cause of cancer-related deaths worldwide. While current treatments such as surveillance, surgery, and radiation are effective, they have their limitations. These can include patient incompliance due to side effects or resistance to hormonal changes, highlighting the need for alternative approaches. Human microbiota, a complex and dynamic host, plays a significant role in the homeostasis and is associated with several diseases or cancers in cases of dysregulation and dysbiosis. Research on fecal microbiota profiling and its association with certain cancers has opened new possibilities for preventing and managing tumor progression. One such possibility is fecal microbial transplantation (FMT). Studies show that different composition of urinary microbiota is found in various urinary tract diseases. Gut microbiota can regulate immune response against tumors; therefore, FMT may help modulate gut microbiota in a way that potentially enhances responses to immune checkpoint inhibitors, as suggested by emerging evidence in other cancers, though this needs further validation in PCa. Nevertheless, long-term complications and the safety of FMT are still questioned. We reviewed the roles of gut microbiota in PCa and suggested FMT as a potential tool in the treatment of PCa, which needs further investigations.http://www.sciencedirect.com/science/article/pii/S2666517425000823Fecal microbiota transplantationGastrointestinal microbiomeProstatic neoplasmsMicrobiotaDysbiosis |
| spellingShingle | Rasoul Ebrahimi Shahrzad Shahrokhi Nejad Mehra Fekri Seyed Aria Nejadghaderi Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy Current Research in Microbial Sciences Fecal microbiota transplantation Gastrointestinal microbiome Prostatic neoplasms Microbiota Dysbiosis |
| title | Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy |
| title_full | Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy |
| title_fullStr | Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy |
| title_full_unstemmed | Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy |
| title_short | Advancing prostate cancer treatment: the role of fecal microbiota transplantation as an adjuvant therapy |
| title_sort | advancing prostate cancer treatment the role of fecal microbiota transplantation as an adjuvant therapy |
| topic | Fecal microbiota transplantation Gastrointestinal microbiome Prostatic neoplasms Microbiota Dysbiosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000823 |
| work_keys_str_mv | AT rasoulebrahimi advancingprostatecancertreatmenttheroleoffecalmicrobiotatransplantationasanadjuvanttherapy AT shahrzadshahrokhinejad advancingprostatecancertreatmenttheroleoffecalmicrobiotatransplantationasanadjuvanttherapy AT mehrafekri advancingprostatecancertreatmenttheroleoffecalmicrobiotatransplantationasanadjuvanttherapy AT seyedarianejadghaderi advancingprostatecancertreatmenttheroleoffecalmicrobiotatransplantationasanadjuvanttherapy |