Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something?
Equilibrium radionuclide ventriculography is an established modality to assess the left ventricular (LV) systolic function in several clinical situations. Diastolic parameters can also be extracted from this investigation. The aim of our study is to assess the diastolic function of the left ventricl...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-04-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.139136 |
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| author | Raghava Kashyap Bhagwant Mittal Kuruva Manohar Anish Bhattacharya Ajay Bahl |
| author_facet | Raghava Kashyap Bhagwant Mittal Kuruva Manohar Anish Bhattacharya Ajay Bahl |
| author_sort | Raghava Kashyap |
| collection | DOAJ |
| description | Equilibrium radionuclide ventriculography is an established modality to assess the left ventricular (LV) systolic function in several clinical situations. Diastolic parameters can also be extracted from this investigation. The aim of our study is to assess the diastolic function of the left ventricle in cases of idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy, where systolic dysfunction has been considered of prime pathologic significance. We conducted a retrospective analysis of 89 patients who had undergone radionuclide ventriculography at our department with established diagnosis of IDCM in 59 patients and ischemic cardiomyopathy in remaining 30 patients. Peak filling rate (PFR) was assessed. The PFR was significantly lower in both patients with IDCM (median = 1.61 end diastolic volumes [EDV]/s) and ischemic cardiomyopathy (median = 2.005 EDV/s). 33% of the patients with ischemic cardiomyopathy and ejection fraction (EF) >45% had diastolic dysfunction while 25% of patients with IDCM and EF >45% had low PFR. Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF. Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients. |
| format | Article |
| id | doaj-art-5ecdd90a478541a2a90afe292c800d1e |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2014-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-5ecdd90a478541a2a90afe292c800d1e2025-08-20T01:57:00ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122014-04-011302858710.4103/1450-1147.139136Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something?Raghava Kashyap0Bhagwant Mittal1Kuruva Manohar2Anish Bhattacharya3Ajay Bahl4Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaEquilibrium radionuclide ventriculography is an established modality to assess the left ventricular (LV) systolic function in several clinical situations. Diastolic parameters can also be extracted from this investigation. The aim of our study is to assess the diastolic function of the left ventricle in cases of idiopathic dilated cardiomyopathy (IDCM) and ischemic cardiomyopathy, where systolic dysfunction has been considered of prime pathologic significance. We conducted a retrospective analysis of 89 patients who had undergone radionuclide ventriculography at our department with established diagnosis of IDCM in 59 patients and ischemic cardiomyopathy in remaining 30 patients. Peak filling rate (PFR) was assessed. The PFR was significantly lower in both patients with IDCM (median = 1.61 end diastolic volumes [EDV]/s) and ischemic cardiomyopathy (median = 2.005 EDV/s). 33% of the patients with ischemic cardiomyopathy and ejection fraction (EF) >45% had diastolic dysfunction while 25% of patients with IDCM and EF >45% had low PFR. Diastolic dysfunction can coexist in patients with dilated cardiomyopathy and even in patients with preserved LV EF. Routine evaluation of diastolic function in patients with heart failure can help in elucidation of pathogenesis and management of patients.http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.139136cardiomyopathydiastolic functionejection fractionmultiple gated acquisitionradionuclide ventriculographysystolic function |
| spellingShingle | Raghava Kashyap Bhagwant Mittal Kuruva Manohar Anish Bhattacharya Ajay Bahl Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? World Journal of Nuclear Medicine cardiomyopathy diastolic function ejection fraction multiple gated acquisition radionuclide ventriculography systolic function |
| title | Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? |
| title_full | Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? |
| title_fullStr | Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? |
| title_full_unstemmed | Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? |
| title_short | Left Ventricular Diastolic Parameters in Dilated Cardiomypoathy: Are We Missing Out on Something? |
| title_sort | left ventricular diastolic parameters in dilated cardiomypoathy are we missing out on something |
| topic | cardiomyopathy diastolic function ejection fraction multiple gated acquisition radionuclide ventriculography systolic function |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/1450-1147.139136 |
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