Hypoxia-ischemia and sexual dimorphism: modeling mitochondrial dysfunction using brain organoids

Abstract Hypoxic–ischemic encephalopathy (HIE) is a leading cause of neurodevelopmental morbidities in full-term infants. There is strong evidence of sexual differences in hypoxic-ischemic (HI) injury where male neonates are at higher risk as they are subject to more pronounced neurological deficits...

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Bibliographic Details
Main Authors: Romane Gaston-Breton, Clémence Disdier, Henrik Hagberg, Aloïse Mabondzo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell & Bioscience
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Online Access:https://doi.org/10.1186/s13578-025-01402-0
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