Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer
Introduction. Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angioge...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/6578273 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567865435226112 |
|---|---|
| author | Mladen Pavlovic Nevena Gajovic Milena Jurisevic Slobodanka Mitrovic Gordana Radosavljevic Jelena Pantic Nebojsa Arsenijevic Ivan Jovanovic |
| author_facet | Mladen Pavlovic Nevena Gajovic Milena Jurisevic Slobodanka Mitrovic Gordana Radosavljevic Jelena Pantic Nebojsa Arsenijevic Ivan Jovanovic |
| author_sort | Mladen Pavlovic |
| collection | DOAJ |
| description | Introduction. Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects. Material and Methods. The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed. Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry. Results. IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III). Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer. Microvascular density was diminished in diffuse type of gastric cancer. Conclusions. Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes. This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer. |
| format | Article |
| id | doaj-art-5ec39fec11474c68a2632dd21ec31711 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-5ec39fec11474c68a2632dd21ec317112025-02-03T01:00:23ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/65782736578273Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric CancerMladen Pavlovic0Nevena Gajovic1Milena Jurisevic2Slobodanka Mitrovic3Gordana Radosavljevic4Jelena Pantic5Nebojsa Arsenijevic6Ivan Jovanovic7Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, SerbiaDepartment of Pathology, Faculty of Medical Sciences, University of Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, SerbiaCenter for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, SerbiaIntroduction. Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects. Material and Methods. The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed. Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry. Results. IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III). Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer. Microvascular density was diminished in diffuse type of gastric cancer. Conclusions. Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes. This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer.http://dx.doi.org/10.1155/2018/6578273 |
| spellingShingle | Mladen Pavlovic Nevena Gajovic Milena Jurisevic Slobodanka Mitrovic Gordana Radosavljevic Jelena Pantic Nebojsa Arsenijevic Ivan Jovanovic Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer Gastroenterology Research and Practice |
| title | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
| title_full | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
| title_fullStr | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
| title_full_unstemmed | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
| title_short | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
| title_sort | diverse expression of il 32 in diffuse and intestinal types of gastric cancer |
| url | http://dx.doi.org/10.1155/2018/6578273 |
| work_keys_str_mv | AT mladenpavlovic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT nevenagajovic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT milenajurisevic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT slobodankamitrovic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT gordanaradosavljevic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT jelenapantic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT nebojsaarsenijevic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer AT ivanjovanovic diverseexpressionofil32indiffuseandintestinaltypesofgastriccancer |