Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

Abstract Even though the number of patients suffering from Alzheimer’s Disease (AD) is rapidly growing worldwide, only a few symptomatic treatments have been approved for clinical use, pointing out the urgent need for more effective disease-modifying therapies that actually alter the progression of...

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Main Authors:	Valentina Latina, Margherita De Introna, Francesca Malerba, Rita Florio, Bijorn Omar Balzamino, Giuseppe Di Natale, Michele Francesco Maria Sciacca, Giuseppe Pappalardo, Alessandra Micera, Annabella Pignataro, Pietro Calissano, Giuseppina Amadoro
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Acta Neuropathologica Communications
Subjects:	Alzheimer’s Disease (AD) Tau protein Amyloid beta (Aβ) Preclinical animal model Immunotherapy
Online Access:	https://doi.org/10.1186/s40478-025-02022-y
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Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

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