Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

Abstract Even though the number of patients suffering from Alzheimer’s Disease (AD) is rapidly growing worldwide, only a few symptomatic treatments have been approved for clinical use, pointing out the urgent need for more effective disease-modifying therapies that actually alter the progression of...

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Main Authors: Valentina Latina, Margherita De Introna, Francesca Malerba, Rita Florio, Bijorn Omar Balzamino, Giuseppe Di Natale, Michele Francesco Maria Sciacca, Giuseppe Pappalardo, Alessandra Micera, Annabella Pignataro, Pietro Calissano, Giuseppina Amadoro
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s Disease (AD)
Tau protein
Amyloid beta (Aβ)
Preclinical animal model
Immunotherapy
Online Access:https://doi.org/10.1186/s40478-025-02022-y
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