Circulating Endothelial Microparticles in Diabetes Mellitus
Background. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the cellular adhesion molecule (CAM) pr...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/250476 |
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| author | A. F. Tramontano R. Lyubarova J. Tsiakos T. Palaia J. R. DeLeon L. Ragolia |
| author_facet | A. F. Tramontano R. Lyubarova J. Tsiakos T. Palaia J. R. DeLeon L. Ragolia |
| author_sort | A. F. Tramontano |
| collection | DOAJ |
| description | Background. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization.
Methods and Results. EMPs were analyzed by flow cytometry. The absolute median number of EMPs (EMPs/𝜇L) specific for CD31, CD105, and CD106 was significantly increased in the DM population. The ratio of CD62E/CD31 EMP populations reflected an apoptotic process.
Conclusion. Circulating CD31+, CD105+, and CD106+ EMPs were significantly elevated in patients with DM. EMPs were the only independent predictors of DM in our study cohort. In addition, the EMP immunophenotype reflected an apoptotic process. Circulating EMPs may provide new options for risk assessment. |
| format | Article |
| id | doaj-art-5ec222d6652c48fbaaaefcee1c2374e5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5ec222d6652c48fbaaaefcee1c2374e52025-02-03T01:28:41ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/250476250476Circulating Endothelial Microparticles in Diabetes MellitusA. F. Tramontano0R. Lyubarova1J. Tsiakos2T. Palaia3J. R. DeLeon4L. Ragolia5Division of Cardiology, Fletcher Allen Health Care and the University of Vermont School of Medicine, Burlington, VT 05401, USADivision of Cardiology, Department of Medicine, Albany Medical Center, Albany, NY 12208, USADivision of Cardiology, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USAVascular Biology Institute, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USADivision of Cardiology, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USAVascular Biology Institute, Stony Brook University School of Medicine at Winthrop-University Hospital, Mineola, NY 11501, USABackground. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization. Methods and Results. EMPs were analyzed by flow cytometry. The absolute median number of EMPs (EMPs/𝜇L) specific for CD31, CD105, and CD106 was significantly increased in the DM population. The ratio of CD62E/CD31 EMP populations reflected an apoptotic process. Conclusion. Circulating CD31+, CD105+, and CD106+ EMPs were significantly elevated in patients with DM. EMPs were the only independent predictors of DM in our study cohort. In addition, the EMP immunophenotype reflected an apoptotic process. Circulating EMPs may provide new options for risk assessment.http://dx.doi.org/10.1155/2010/250476 |
| spellingShingle | A. F. Tramontano R. Lyubarova J. Tsiakos T. Palaia J. R. DeLeon L. Ragolia Circulating Endothelial Microparticles in Diabetes Mellitus Mediators of Inflammation |
| title | Circulating Endothelial Microparticles in Diabetes Mellitus |
| title_full | Circulating Endothelial Microparticles in Diabetes Mellitus |
| title_fullStr | Circulating Endothelial Microparticles in Diabetes Mellitus |
| title_full_unstemmed | Circulating Endothelial Microparticles in Diabetes Mellitus |
| title_short | Circulating Endothelial Microparticles in Diabetes Mellitus |
| title_sort | circulating endothelial microparticles in diabetes mellitus |
| url | http://dx.doi.org/10.1155/2010/250476 |
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