Impaired DNAJB2 Response to Heat Shock in Fibroblasts from a Neuropathy Patient with <i>DNAJB2/HSJ1</i> Mutation: Cystamine as a Potential Therapeutic Intervention

Impaired DNAJB2 Response to Heat Shock in Fibroblasts from a Neuropathy Patient with <i>DNAJB2/HSJ1</i> Mutation: Cystamine as a Potential Therapeutic Intervention

<b>Background and Objectives:</b> Neuropathy is a debilitating disorder characterized by peripheral nerve dysfunction and damage to sensory, motor, and autonomic neurons and their axons. While homozygous mutations in DNAJB2/HSJ1 have been linked to early-onset neuropathy, a heterozygous...

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Bibliographic Details
Main Authors: Raj Kumar Pradhan, Nikolas G. Kinney, Brigid K. Jensen, Hristelina Ilieva
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Neurology International
Subjects:
neuropathy
heat shock proteins
DNAJB2
HSP40
HSJ1
Cystamine
Online Access:https://www.mdpi.com/2035-8377/17/5/73
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