A temporal model of tumor-immune dynamics during the metastatic progression of high-grade serous ovarian cancer

A temporal model of tumor-immune dynamics during the metastatic progression of high-grade serous ovarian cancer

Abstract Patients with high-grade serous ovarian cancer (HGSOC) typically present with widespread metastasis, obscuring a temporal understanding of tumor-immune dynamics. To address this, we perform multi-site global proteomics alongside matched immunohistochemistry (IHC) for CD4⁺ and CD8⁺ tumor-inf...

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Bibliographic Details
Main Authors: Donagh Egan, Kate Glennon, Ann Treacy, Aurelie Fabre, Janet McCormack, Salisha Hill, Ryan Morrison, Vadim Zhernovkov, Daniel Liebler, Walter Kolch, Donal Brennan
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00973-y
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