Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo
99mTc derived from 99Mo，stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide. Its current production mainly relies on some near-retirement nuclear reactors. Compared to reactors，particle accelerators have extremely low construction，operational，and mainte...
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| Format: | Article |
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Editorial Board of Journal of Isotopes
2025-02-01
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| Series: | Journal of Isotopes |
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| Online Access: | https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.081 |
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| author | Desheng CHEN Qinggang HUANG Shiwei CAO Zhi QIN |
| author_facet | Desheng CHEN Qinggang HUANG Shiwei CAO Zhi QIN |
| author_sort | Desheng CHEN |
| collection | DOAJ |
| description | 99mTc derived from 99Mo，stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide. Its current production mainly relies on some near-retirement nuclear reactors. Compared to reactors，particle accelerators have extremely low construction，operational，and maintenance costs，and their layouts are highly flexible. Given these circumstances，the production of 99Mo/99mTc by accelerator has become a research hotspot，with using electron-beam to irradiate 100Mo to produce 99Mo and proton-beam to irradiate 100Mo to produce 99mTc being the two most feasible methods. This article compares the advantages and disadvantages of two methods for preparing 99Mo/99mTc based on accelerators through experiments and Monte Carlo simulations. Direct production of 99mTc by proton accelerators，the advantage is higher yield，but other Tc isotopes，especially 99gTc，are produced alongside. In contrast，irradiating 100Mo by electrons not only can produce high-purity 99Mo with a simpler chemical separation process，but also make it suitable for preparing 99Mo-99mTc generators，which is relatively more advantageous. |
| format | Article |
| id | doaj-art-5eaa1cf091d04c40a7dd4896c0d159d6 |
| institution | Kabale University |
| issn | 1000-7512 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Editorial Board of Journal of Isotopes |
| record_format | Article |
| series | Journal of Isotopes |
| spelling | doaj-art-5eaa1cf091d04c40a7dd4896c0d159d62025-01-24T06:37:08ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75122025-02-01381303810.7538/tws.2024.youxian.081202407081Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100MoDesheng CHEN0Qinggang HUANG1Shiwei CAO2Zhi QIN3Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China99mTc derived from 99Mo，stands as the preeminent radiopharmaceutical employed extensively in medical diagnostics worldwide. Its current production mainly relies on some near-retirement nuclear reactors. Compared to reactors，particle accelerators have extremely low construction，operational，and maintenance costs，and their layouts are highly flexible. Given these circumstances，the production of 99Mo/99mTc by accelerator has become a research hotspot，with using electron-beam to irradiate 100Mo to produce 99Mo and proton-beam to irradiate 100Mo to produce 99mTc being the two most feasible methods. This article compares the advantages and disadvantages of two methods for preparing 99Mo/99mTc based on accelerators through experiments and Monte Carlo simulations. Direct production of 99mTc by proton accelerators，the advantage is higher yield，but other Tc isotopes，especially 99gTc，are produced alongside. In contrast，irradiating 100Mo by electrons not only can produce high-purity 99Mo with a simpler chemical separation process，but also make it suitable for preparing 99Mo-99mTc generators，which is relatively more advantageous.https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.081protonelectronacceleratormonte carlo simulation99mo/99mtc |
| spellingShingle | Desheng CHEN Qinggang HUANG Shiwei CAO Zhi QIN Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo Journal of Isotopes proton electron accelerator monte carlo simulation 99mo/99mtc |
| title | Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo |
| title_full | Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo |
| title_fullStr | Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo |
| title_full_unstemmed | Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo |
| title_short | Comparative Experiment on the Preparation of 99Mo/99mTc via Electron and Proton Irradiation of 100Mo |
| title_sort | comparative experiment on the preparation of 99mo 99mtc via electron and proton irradiation of 100mo |
| topic | proton electron accelerator monte carlo simulation 99mo/99mtc |
| url | https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.081 |
| work_keys_str_mv | AT deshengchen comparativeexperimentonthepreparationof99mo99mtcviaelectronandprotonirradiationof100mo AT qingganghuang comparativeexperimentonthepreparationof99mo99mtcviaelectronandprotonirradiationof100mo AT shiweicao comparativeexperimentonthepreparationof99mo99mtcviaelectronandprotonirradiationof100mo AT zhiqin comparativeexperimentonthepreparationof99mo99mtcviaelectronandprotonirradiationof100mo |