Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report
Background. Vaccines, which make it possible to be protected from many life-threatening infectious diseases, have been used safely and effectively for years. Most vaccines used today contain a variety of adjuvants and exogenous proteins. Severe reactions, in addition to transient and self-lim...
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Hacettepe University Institute of Child Health
2022-04-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/158 |
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| author | Özge Atay Suna Asilsoy Gizem Atakul Serdar Al Özge Kangallı Boyacıoğlu Tayfun Çinleti Nevin Uzuner Özlem Giray Bozkaya Özkan Karaman |
| author_facet | Özge Atay Suna Asilsoy Gizem Atakul Serdar Al Özge Kangallı Boyacıoğlu Tayfun Çinleti Nevin Uzuner Özlem Giray Bozkaya Özkan Karaman |
| author_sort | Özge Atay |
| collection | DOAJ |
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Background. Vaccines, which make it possible to be protected from many life-threatening infectious diseases, have been used safely and effectively for years. Most vaccines used today contain a variety of adjuvants and exogenous proteins. Severe reactions, in addition to transient and self-limiting mild reactions, mostly caused by these components, have been reported. The effects of vaccine adjuvants on the pathogenesis of immunemediated diseases are still under investigation. The syndrome called Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been defined in the literature.
Case. We found a novel mutation of autoinflammatory diseases in the genetic analysis of our patient. The patient developed symptoms of prolonged fever, rash, arthritis and serositis after multicomponent serogroup B meningococcal (Bexsero®) vaccination, without a previously known rheumatic disease. In the presence of clinical findings in our patient, the diagnostic criteria of ASIA syndrome were met.
Conclusion. To the best of our knowledge, this is the first case report of a patient diagnosed with the autoinflammatory disease with a novel mutation after Bexsero® vaccination. We consider that genetic examinations will be useful in patients with a systemic vaccine reaction in the presence of ASIA when diagnostic criteria are met.
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| format | Article |
| id | doaj-art-5ea1708cfb4144b28124de4642c15e9c |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-5ea1708cfb4144b28124de4642c15e9c2025-08-20T02:55:41ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212022-04-0164210.24953/turkjped.2020.2842Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case reportÖzge Atay0Suna Asilsoy1Gizem Atakul2Serdar Al3Özge Kangallı Boyacıoğlu4Tayfun Çinleti5Nevin Uzuner6Özlem Giray Bozkaya7Özkan KaramanDepartments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Genetics, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Immunology and Allergy, okuz Eylül University Faculty of Medicine, İzmir, Turkey.Departments of Pediatric Genetics, okuz Eylül University Faculty of Medicine, İzmir, Turkey. Background. Vaccines, which make it possible to be protected from many life-threatening infectious diseases, have been used safely and effectively for years. Most vaccines used today contain a variety of adjuvants and exogenous proteins. Severe reactions, in addition to transient and self-limiting mild reactions, mostly caused by these components, have been reported. The effects of vaccine adjuvants on the pathogenesis of immunemediated diseases are still under investigation. The syndrome called Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been defined in the literature. Case. We found a novel mutation of autoinflammatory diseases in the genetic analysis of our patient. The patient developed symptoms of prolonged fever, rash, arthritis and serositis after multicomponent serogroup B meningococcal (Bexsero®) vaccination, without a previously known rheumatic disease. In the presence of clinical findings in our patient, the diagnostic criteria of ASIA syndrome were met. Conclusion. To the best of our knowledge, this is the first case report of a patient diagnosed with the autoinflammatory disease with a novel mutation after Bexsero® vaccination. We consider that genetic examinations will be useful in patients with a systemic vaccine reaction in the presence of ASIA when diagnostic criteria are met. https://turkjpediatr.org/article/view/158ASIA syndromeadjuvantsautoimmune diseasescryopyrin-associated periodic syndromesvaccines |
| spellingShingle | Özge Atay Suna Asilsoy Gizem Atakul Serdar Al Özge Kangallı Boyacıoğlu Tayfun Çinleti Nevin Uzuner Özlem Giray Bozkaya Özkan Karaman Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report The Turkish Journal of Pediatrics ASIA syndrome adjuvants autoimmune diseases cryopyrin-associated periodic syndromes vaccines |
| title | Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report |
| title_full | Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report |
| title_fullStr | Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report |
| title_full_unstemmed | Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report |
| title_short | Autoimmune/autoinflammatory syndrome induced by adjuvants after multi-component meningococcal serogroup B vaccination in a 7-year-old girl: a case report |
| title_sort | autoimmune autoinflammatory syndrome induced by adjuvants after multi component meningococcal serogroup b vaccination in a 7 year old girl a case report |
| topic | ASIA syndrome adjuvants autoimmune diseases cryopyrin-associated periodic syndromes vaccines |
| url | https://turkjpediatr.org/article/view/158 |
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