Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system

Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system

Human induced pluripotent stem (hiPS) cells are a powerful tool for biomedical research. The ability to create patient-specifc pluripotent cells and their subsequent differentiation into any somatic cell type makes hiPS cells a valuable object for creating in vitro models of human diseases, screening...

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Bibliographic Details
Main Author: М. М. Gridina
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2019-01-01
Series:Вавиловский журнал генетики и селекции
Subjects:
human induced pluripotent stem cells
crispr/cas9 system
genome editing
knock-in efciency
Online Access:https://vavilov.elpub.ru/jour/article/view/1805
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