PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway

PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway

Abstract Particulate matter 2.5 (PM2.5) is a risk factor for lung cancer. In this study, we investigated the molecular mechanisms of PM2.5 exposure on lung cancer progression. We found that short‐term exposure to PM2.5 for 24 h activated the EGFR pathway in lung cancer cells (EGFR wild‐type and muta...

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Main Authors: Tong‐Hong Wang, Kuo‐Yen Huang, Chin‐Chuan Chen, Ya‐Hsuan Chang, Hsuan‐Yu Chen, Chuen Hsueh, Yi‐Tsen Liu, Shuenn‐Chen Yang, Pan‐Chyr Yang, Chi‐Yuan Chen
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:EMBO Molecular Medicine
Subjects:
AhR
EGFR
lung cancer
PM2.5
TMPRSS2
Online Access:https://doi.org/10.15252/emmm.202217014
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