Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity
Abstract Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel HKU2-related coronavirus of bat origin, is a newly emerged swine enteropathogenic coronavirus that causes severe diarrhoea in piglets. SADS-CoV has a broad cell tropism with the capability to infect a wide variety of cells from...
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| Language: | English |
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BMC
2025-01-01
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| Series: | Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s13567-024-01436-1 |
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| author | Fei Zhao Xiao Cong Xiaobo Huang Yi Zheng Qin Zhao Yiping Wen Rui Wu Senyan Du Sanjie Cao Feng Cong Yiping Wang |
| author_facet | Fei Zhao Xiao Cong Xiaobo Huang Yi Zheng Qin Zhao Yiping Wen Rui Wu Senyan Du Sanjie Cao Feng Cong Yiping Wang |
| author_sort | Fei Zhao |
| collection | DOAJ |
| description | Abstract Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel HKU2-related coronavirus of bat origin, is a newly emerged swine enteropathogenic coronavirus that causes severe diarrhoea in piglets. SADS-CoV has a broad cell tropism with the capability to infect a wide variety of cells from human and diverse animals, which implicates its ability to hold high risks of cross-species transmission. The intracellular antiviral immunity, comprised of the intrinsic and innate immunity, represents the first line of host defence against viral infection prior to the onset of adaptive immunity. To date, there are no vaccines and drugs approved to prevent or treat SADS-CoV infection. Understanding of the mutual relationship between SADS-CoV infection and host immunity is crucial for the development of novel vaccines and drugs against SADS-CoV. Here, we review recent advancements in our understanding of the interplay between SADS-CoV infection and the host intrinsic and innate immunity. The extensive and in-depth investigation on their interactive relationship will contribute to the identification of new targets for developing intervention strategies to control SADS-CoV infection. |
| format | Article |
| id | doaj-art-5e94f1ad58a2463980ef7925c9a402f7 |
| institution | Kabale University |
| issn | 1297-9716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj-art-5e94f1ad58a2463980ef7925c9a402f72025-01-12T12:35:29ZengBMCVeterinary Research1297-97162025-01-0156111410.1186/s13567-024-01436-1Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunityFei Zhao0Xiao Cong1Xiaobo Huang2Yi Zheng3Qin Zhao4Yiping Wen5Rui Wu6Senyan Du7Sanjie Cao8Feng Cong9Yiping Wang10Department of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityGuangdong Laboratory Animals Monitoring InstituteDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityGuangdong Laboratory Animals Monitoring InstituteDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityAbstract Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel HKU2-related coronavirus of bat origin, is a newly emerged swine enteropathogenic coronavirus that causes severe diarrhoea in piglets. SADS-CoV has a broad cell tropism with the capability to infect a wide variety of cells from human and diverse animals, which implicates its ability to hold high risks of cross-species transmission. The intracellular antiviral immunity, comprised of the intrinsic and innate immunity, represents the first line of host defence against viral infection prior to the onset of adaptive immunity. To date, there are no vaccines and drugs approved to prevent or treat SADS-CoV infection. Understanding of the mutual relationship between SADS-CoV infection and host immunity is crucial for the development of novel vaccines and drugs against SADS-CoV. Here, we review recent advancements in our understanding of the interplay between SADS-CoV infection and the host intrinsic and innate immunity. The extensive and in-depth investigation on their interactive relationship will contribute to the identification of new targets for developing intervention strategies to control SADS-CoV infection.https://doi.org/10.1186/s13567-024-01436-1Swine acute diarrhoea syndrome coronavirusSADS-CoVintrinsic immunityinnate immunityimmune evasion |
| spellingShingle | Fei Zhao Xiao Cong Xiaobo Huang Yi Zheng Qin Zhao Yiping Wen Rui Wu Senyan Du Sanjie Cao Feng Cong Yiping Wang Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity Veterinary Research Swine acute diarrhoea syndrome coronavirus SADS-CoV intrinsic immunity innate immunity immune evasion |
| title | Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| title_full | Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| title_fullStr | Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| title_full_unstemmed | Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| title_short | Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| title_sort | interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity |
| topic | Swine acute diarrhoea syndrome coronavirus SADS-CoV intrinsic immunity innate immunity immune evasion |
| url | https://doi.org/10.1186/s13567-024-01436-1 |
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