RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2
Abstract Kidney cancer may result from different gene mutations, each contributing to different histological subtypes and prognoses. RAD52 motif-containing 1 (RDM1) regulates multiple cancer pathways, but its role in ccRCC is unknown to date. According to our results, RDM1 expression increased in cc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-07230-z |
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| author | Xiuming Li Hui Liu Yujie Wei Anxin Wang Chengcheng Lv Yu Zeng |
| author_facet | Xiuming Li Hui Liu Yujie Wei Anxin Wang Chengcheng Lv Yu Zeng |
| author_sort | Xiuming Li |
| collection | DOAJ |
| description | Abstract Kidney cancer may result from different gene mutations, each contributing to different histological subtypes and prognoses. RAD52 motif-containing 1 (RDM1) regulates multiple cancer pathways, but its role in ccRCC is unknown to date. According to our results, RDM1 expression increased in ccRCC cells, which was correlated to poor survival in ccRCC patients. Knockdown of RDM1 arrested the cell cycle, promoted cell apoptosis, and apparently suppressed ccRCC cell growth in vitro and in vivo. From the mechanism perspective, RDM1 drove MCM2 to modulate ccRCC cell cycle. Thus, RDM1 inhibition blocks cell cycle progression, suppresses ccRCC cell growth, and is a promising approach for treating ccRCC. |
| format | Article |
| id | doaj-art-5e8f9f805b694e5190de6cb9fcc94d4e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-5e8f9f805b694e5190de6cb9fcc94d4e2025-08-20T04:01:26ZengNature PortfolioScientific Reports2045-23222025-07-0115111410.1038/s41598-025-07230-zRDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2Xiuming Li0Hui Liu1Yujie Wei2Anxin Wang3Chengcheng Lv4Yu Zeng5Hebei Key Laboratory of Panvascular DiseasesDepartment of Pharmacology, College of Traditional Chinese Medicine, Chengde Medical UniversityDepartment of Urology, Affiliated Hospital of Chengde Medical UniversityDepartment of Pharmacology, College of Traditional Chinese Medicine, Chengde Medical UniversityDepartment of Urology, the Cancer Hospital of China Medical University & Liaoning Cancer Hospital and InstituteDepartment of Urology, the Cancer Hospital of China Medical University & Liaoning Cancer Hospital and InstituteAbstract Kidney cancer may result from different gene mutations, each contributing to different histological subtypes and prognoses. RAD52 motif-containing 1 (RDM1) regulates multiple cancer pathways, but its role in ccRCC is unknown to date. According to our results, RDM1 expression increased in ccRCC cells, which was correlated to poor survival in ccRCC patients. Knockdown of RDM1 arrested the cell cycle, promoted cell apoptosis, and apparently suppressed ccRCC cell growth in vitro and in vivo. From the mechanism perspective, RDM1 drove MCM2 to modulate ccRCC cell cycle. Thus, RDM1 inhibition blocks cell cycle progression, suppresses ccRCC cell growth, and is a promising approach for treating ccRCC.https://doi.org/10.1038/s41598-025-07230-z |
| spellingShingle | Xiuming Li Hui Liu Yujie Wei Anxin Wang Chengcheng Lv Yu Zeng RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 Scientific Reports |
| title | RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 |
| title_full | RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 |
| title_fullStr | RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 |
| title_full_unstemmed | RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 |
| title_short | RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2 |
| title_sort | rdm1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating mcm2 |
| url | https://doi.org/10.1038/s41598-025-07230-z |
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