NOD2-NLRP3 Axis and Asthma
Xulong Cai Department of Pediatrics, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of ChinaCorrespondence: Xulong Cai, Email caixulong2017@163.comAbstract: Patients with asthma frequently experience recurrent symptoms including cou...
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Dove Medical Press
2025-05-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/nod2-nlrp3-axis-and-asthma-peer-reviewed-fulltext-article-JAA |
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| author | Cai X |
| author_facet | Cai X |
| author_sort | Cai X |
| collection | DOAJ |
| description | Xulong Cai Department of Pediatrics, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of ChinaCorrespondence: Xulong Cai, Email caixulong2017@163.comAbstract: Patients with asthma frequently experience recurrent symptoms including coughing, wheezing, shortness of breath, and chest tightness. Asthma is a common public health concern. It is characterized by chronic airway inflammation. However, The pathogenesis of asthma is complex. Inflammasomes are signaling platforms that regulate the inflammatory response. There is a correlation between inflammasomes and asthma. Pattern recognition receptors recognize danger signals and participate in inflammasome activation. Nucleotide-binding and oligomerization domain-containing 2 (NOD2), a pattern recognition receptor, senses microbial components and triggers immune responses. There have been studies showing a correlation between NOD2 and asthma. The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) participates in the formation of inflammasomes. NLRP3 are involved in asthma pathogenesis. In this review, we discuss the roles of NOD2 and NLRP3 in the pathogenesis of asthma.Keywords: NOD2, NLRP3, inflammasome, asthma |
| format | Article |
| id | doaj-art-5e87619c05be4bf68b34ebf4b3c03dde |
| institution | DOAJ |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj-art-5e87619c05be4bf68b34ebf4b3c03dde2025-08-20T03:23:59ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-05-01Volume 18Issue 1769777103199NOD2-NLRP3 Axis and AsthmaCai X0Department of PediatricsXulong Cai Department of Pediatrics, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of ChinaCorrespondence: Xulong Cai, Email caixulong2017@163.comAbstract: Patients with asthma frequently experience recurrent symptoms including coughing, wheezing, shortness of breath, and chest tightness. Asthma is a common public health concern. It is characterized by chronic airway inflammation. However, The pathogenesis of asthma is complex. Inflammasomes are signaling platforms that regulate the inflammatory response. There is a correlation between inflammasomes and asthma. Pattern recognition receptors recognize danger signals and participate in inflammasome activation. Nucleotide-binding and oligomerization domain-containing 2 (NOD2), a pattern recognition receptor, senses microbial components and triggers immune responses. There have been studies showing a correlation between NOD2 and asthma. The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) participates in the formation of inflammasomes. NLRP3 are involved in asthma pathogenesis. In this review, we discuss the roles of NOD2 and NLRP3 in the pathogenesis of asthma.Keywords: NOD2, NLRP3, inflammasome, asthmahttps://www.dovepress.com/nod2-nlrp3-axis-and-asthma-peer-reviewed-fulltext-article-JAANOD2NLRP3InflammasomeAsthma |
| spellingShingle | Cai X NOD2-NLRP3 Axis and Asthma Journal of Asthma and Allergy NOD2 NLRP3 Inflammasome Asthma |
| title | NOD2-NLRP3 Axis and Asthma |
| title_full | NOD2-NLRP3 Axis and Asthma |
| title_fullStr | NOD2-NLRP3 Axis and Asthma |
| title_full_unstemmed | NOD2-NLRP3 Axis and Asthma |
| title_short | NOD2-NLRP3 Axis and Asthma |
| title_sort | nod2 nlrp3 axis and asthma |
| topic | NOD2 NLRP3 Inflammasome Asthma |
| url | https://www.dovepress.com/nod2-nlrp3-axis-and-asthma-peer-reviewed-fulltext-article-JAA |
| work_keys_str_mv | AT caix nod2nlrp3axisandasthma |