Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects.
<h4>Background</h4>The association between Aurora-A V57I (rs1047972, G>A) polymorphism and cancer susceptibility has been widely studied. However, the results are inconsistent.<h4>Methodology/principal findings</h4>To obtain a more precise evaluation of the relationship, w...
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| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090328&type=printable |
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| author | Weifeng Tang Hao Qiu Heping Jiang Lixin Wang Bin Sun Haiyong Gu |
| author_facet | Weifeng Tang Hao Qiu Heping Jiang Lixin Wang Bin Sun Haiyong Gu |
| author_sort | Weifeng Tang |
| collection | DOAJ |
| description | <h4>Background</h4>The association between Aurora-A V57I (rs1047972, G>A) polymorphism and cancer susceptibility has been widely studied. However, the results are inconsistent.<h4>Methodology/principal findings</h4>To obtain a more precise evaluation of the relationship, we performed a meta-analysis of 14 case-control studies involving a total of 11,245 cancer cases and 16,024 controls. Our results demonstrated that there was a borderline evidence of an association between the Aurora-A V57I polymorphism and the decreased risk of overall cancer in two genetic models: AA vs. GA+GG and AA vs. GG. In a stratified analysis by cancer type, significant association between Aurora-A V57I polymorphism and the decreased risk of breast cancer was identified in one genetic model: AA vs. GG. In a stratified analysis by ethnicity, in three genetic models, significant decreased cancer risk was observed among Caucasians (AA vs. GA+GG; AA vs. GG and A vs. G) instead of Asians. Furthermore, a stratified analysis by ethnicity in breast cancer subgroup, five genetic models (AA+GA vs. GG; AA vs. GA+GG; AA vs. GG; AA vs. GA and A vs. G), significant decreased cancer risk was observed among Caucasians, but not among Asians. A slight publication bias was observed in our meta-analysis, thus nonparametric "trim-and-fill" method was utilized to detect the stability of our results. The adjusted odds ratios and confidence intervals showed that Aurora-A V57I polymorphism might be a protective factor for cancer risk, suggesting the reliability of our findings.<h4>Conclusion</h4>In summary, this meta-analysis suggests that Aurora-A V57I polymorphism may be a protective factor for cancer risk. |
| format | Article |
| id | doaj-art-5e857083aa4d4788bca39bfad68cca63 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5e857083aa4d4788bca39bfad68cca632025-08-20T02:15:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9032810.1371/journal.pone.0090328Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects.Weifeng TangHao QiuHeping JiangLixin WangBin SunHaiyong Gu<h4>Background</h4>The association between Aurora-A V57I (rs1047972, G>A) polymorphism and cancer susceptibility has been widely studied. However, the results are inconsistent.<h4>Methodology/principal findings</h4>To obtain a more precise evaluation of the relationship, we performed a meta-analysis of 14 case-control studies involving a total of 11,245 cancer cases and 16,024 controls. Our results demonstrated that there was a borderline evidence of an association between the Aurora-A V57I polymorphism and the decreased risk of overall cancer in two genetic models: AA vs. GA+GG and AA vs. GG. In a stratified analysis by cancer type, significant association between Aurora-A V57I polymorphism and the decreased risk of breast cancer was identified in one genetic model: AA vs. GG. In a stratified analysis by ethnicity, in three genetic models, significant decreased cancer risk was observed among Caucasians (AA vs. GA+GG; AA vs. GG and A vs. G) instead of Asians. Furthermore, a stratified analysis by ethnicity in breast cancer subgroup, five genetic models (AA+GA vs. GG; AA vs. GA+GG; AA vs. GG; AA vs. GA and A vs. G), significant decreased cancer risk was observed among Caucasians, but not among Asians. A slight publication bias was observed in our meta-analysis, thus nonparametric "trim-and-fill" method was utilized to detect the stability of our results. The adjusted odds ratios and confidence intervals showed that Aurora-A V57I polymorphism might be a protective factor for cancer risk, suggesting the reliability of our findings.<h4>Conclusion</h4>In summary, this meta-analysis suggests that Aurora-A V57I polymorphism may be a protective factor for cancer risk.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090328&type=printable |
| spellingShingle | Weifeng Tang Hao Qiu Heping Jiang Lixin Wang Bin Sun Haiyong Gu Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. PLoS ONE |
| title | Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. |
| title_full | Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. |
| title_fullStr | Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. |
| title_full_unstemmed | Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. |
| title_short | Aurora-A V57I (rs1047972) polymorphism and cancer susceptibility: a meta-analysis involving 27,269 subjects. |
| title_sort | aurora a v57i rs1047972 polymorphism and cancer susceptibility a meta analysis involving 27 269 subjects |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090328&type=printable |
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