A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study
Purpose: To compare the long-term efficacy between repeated low-level red light (RLRL) therapy and low-dose atropine (LDA) eye drops for myopia control. Methods: Treatment naïve myopic children receiving RLRL or LDA therapy were retrospectively included. The spherical equivalent (SE) and axial lengt...
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Elsevier
2025-10-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025002868 |
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| author | Mingming Zhang Yinghui Shi Yuexin Wang Yangguang Li Jian Qin Xiaobing Wang Ying Jie |
| author_facet | Mingming Zhang Yinghui Shi Yuexin Wang Yangguang Li Jian Qin Xiaobing Wang Ying Jie |
| author_sort | Mingming Zhang |
| collection | DOAJ |
| description | Purpose: To compare the long-term efficacy between repeated low-level red light (RLRL) therapy and low-dose atropine (LDA) eye drops for myopia control. Methods: Treatment naïve myopic children receiving RLRL or LDA therapy were retrospectively included. The spherical equivalent (SE) and axial length (AL) were evaluated at baseline and 6-, 12-, and 24-month follow-up. The myopia progression and regression were compared between groups. Results: In total, 122 myopic children were enrolled. The SE progression and AL elongation were significantly less in the RLRL than in the LDA group at 6 months (P = 0.002, SE; P = 0.004, AL), 12 months (P < 0.001) and 24 months (P < 0.001). For patients with RLRL, the SE progression was greater during the second than the first year (P = 0.05). The proportion of patients with SE regression in the RLRL group was greater than that in the LDA group at 12 months (P = 0.003), and the AL shortening proportion was significantly greater in the RLRL group than in the LDA group at 6 months (P = 0.001), 12 months (P = 0.001), and 24 months (P = 0.049). Eight adverse events were reported in the RLRL group without irreversible structural damage. Conclusion: The present research demonstrates that RLRL treatment is more effective than 0.01 % atropine in delaying myopia progression and observes a greater percentage of patients with SE regression and AL shortening in myopic children over two years. |
| format | Article |
| id | doaj-art-5e82eef5ea744407a8594116bec16b97 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-5e82eef5ea744407a8594116bec16b972025-08-20T05:04:57ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-10-015510475410.1016/j.pdpdt.2025.104754A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective studyMingming Zhang0Yinghui Shi1Yuexin Wang2Yangguang Li3Jian Qin4Xiaobing Wang5Ying Jie6Vision Research Center, Sport and Medicine Integrative Innovation Center, Capital University of Physical Education and Sports, Beijing, ChinaShiyinghui Clinic, Henan province, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing, ChinaShiyinghui Clinic, Henan province, ChinaDepartment of Ophthalmology, Henan Provincial People’s Hospital, Henan Eye Hospital, People’s Hospital of Zhengzhou University, Henan province, ChinaVision Research Center, Sport and Medicine Integrative Innovation Center, Capital University of Physical Education and Sports, Beijing, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Corresponding author at: Vision Research Center, Sport and Medicine Integrative Innovation Center, Capital University of Physical Education and Sports, Beijing, China.Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Corresponding author at: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.Purpose: To compare the long-term efficacy between repeated low-level red light (RLRL) therapy and low-dose atropine (LDA) eye drops for myopia control. Methods: Treatment naïve myopic children receiving RLRL or LDA therapy were retrospectively included. The spherical equivalent (SE) and axial length (AL) were evaluated at baseline and 6-, 12-, and 24-month follow-up. The myopia progression and regression were compared between groups. Results: In total, 122 myopic children were enrolled. The SE progression and AL elongation were significantly less in the RLRL than in the LDA group at 6 months (P = 0.002, SE; P = 0.004, AL), 12 months (P < 0.001) and 24 months (P < 0.001). For patients with RLRL, the SE progression was greater during the second than the first year (P = 0.05). The proportion of patients with SE regression in the RLRL group was greater than that in the LDA group at 12 months (P = 0.003), and the AL shortening proportion was significantly greater in the RLRL group than in the LDA group at 6 months (P = 0.001), 12 months (P = 0.001), and 24 months (P = 0.049). Eight adverse events were reported in the RLRL group without irreversible structural damage. Conclusion: The present research demonstrates that RLRL treatment is more effective than 0.01 % atropine in delaying myopia progression and observes a greater percentage of patients with SE regression and AL shortening in myopic children over two years.http://www.sciencedirect.com/science/article/pii/S1572100025002868MyopiaRepeated low-level red lightLow-dose atropine |
| spellingShingle | Mingming Zhang Yinghui Shi Yuexin Wang Yangguang Li Jian Qin Xiaobing Wang Ying Jie A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study Photodiagnosis and Photodynamic Therapy Myopia Repeated low-level red light Low-dose atropine |
| title | A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study |
| title_full | A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study |
| title_fullStr | A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study |
| title_full_unstemmed | A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study |
| title_short | A comparison of repeated low-level red light and low-dose atropine for myopia control: A two-year retrospective study |
| title_sort | comparison of repeated low level red light and low dose atropine for myopia control a two year retrospective study |
| topic | Myopia Repeated low-level red light Low-dose atropine |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025002868 |
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