Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies

Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies

Background & Aims: The progression of chronic liver disease (CLD) is characterized by excessive extracellular matrix deposition, disrupting hepatic architecture and function. Upon liver injury, hepatic stellate cells (HSCs) differentiate towards myofibroblasts and become inflammatory, prolif...

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Bibliographic Details
Main Authors: Vincent Merens, Elisabeth Knetemann, Elif Gürbüz, Vincent De Smet, Nouredin Messaoudi, Hendrik Reynaert, Stefaan Verhulst, Leo A. van Grunsven
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:JHEP Reports
Subjects:
Chronic liver disease
single-cell RNA-Sequencing
parathyroid hormone
COLEC10
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002271
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