ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ
Nicorandil is a dual pharmacological mechanism anti-anginal agent with adenosinetriphosphat-esensitive potassium (Кatp) channel agonist and nitrate-like properties. The aim of this review is to provide an update on the efficacy of treatment with nicorandil. First, the rationale for nicorandil treatm...
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| Language: | Russian |
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SINAPS LLC
2012-02-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/52 |
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| author | Ю. Б. Белоусов |
| author_facet | Ю. Б. Белоусов |
| author_sort | Ю. Б. Белоусов |
| collection | DOAJ |
| description | Nicorandil is a dual pharmacological mechanism anti-anginal agent with adenosinetriphosphat-esensitive potassium (Кatp) channel agonist and nitrate-like properties. The aim of this review is to provide an update on the efficacy of treatment with nicorandil. First, the rationale for nicorandil treatment and its pharmacological effects are reviewed. We explain the mechanisms underlying ischemic preconditioning, with a focus on those that involve the KAТР. Next, clinical practice related lo ischemic preconditioning and pharmacological preconditioning with nicorandil as well as other favourable mechanisms of improvement of prognosis, in which it plays a role in improving endothelial function, modulating autonomic nervous system activity and stabilizing plaque are summarized. Finally, the tolerability of nicorandil is discussed. |
| format | Article |
| id | doaj-art-5e7e1af6949c4d7a87e57d9fbf47d90e |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-5e7e1af6949c4d7a87e57d9fbf47d90e2025-08-20T03:38:16ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642012-02-0101465210.20514/2226-6704-2012-0-1-46-5266ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯЮ. Б. Белоусов0ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.ПироговаNicorandil is a dual pharmacological mechanism anti-anginal agent with adenosinetriphosphat-esensitive potassium (Кatp) channel agonist and nitrate-like properties. The aim of this review is to provide an update on the efficacy of treatment with nicorandil. First, the rationale for nicorandil treatment and its pharmacological effects are reviewed. We explain the mechanisms underlying ischemic preconditioning, with a focus on those that involve the KAТР. Next, clinical practice related lo ischemic preconditioning and pharmacological preconditioning with nicorandil as well as other favourable mechanisms of improvement of prognosis, in which it plays a role in improving endothelial function, modulating autonomic nervous system activity and stabilizing plaque are summarized. Finally, the tolerability of nicorandil is discussed.https://www.medarhive.ru/jour/article/view/52nicorandilcardioprotectorsкatp-channelsischemic heart disease |
| spellingShingle | Ю. Б. Белоусов ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ Архивъ внутренней медицины nicorandil cardioprotectors кatp-channels ischemic heart disease |
| title | ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ |
| title_full | ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ |
| title_fullStr | ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ |
| title_full_unstemmed | ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ |
| title_short | ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ |
| title_sort | применение никорандила при сердечно сосудистых заболеваниях и оптимизация схем его назначения |
| topic | nicorandil cardioprotectors кatp-channels ischemic heart disease |
| url | https://www.medarhive.ru/jour/article/view/52 |
| work_keys_str_mv | AT ûbbelousov primenenienikorandilapriserdečnososudistyhzabolevaniâhioptimizaciâshemegonaznačeniâ |