Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients
Background: Diabetes mellitus is an endocrine disorder. It is one of the leading causes of morbidity and mortality due to its role in the development of microvascular and macrovascular complications. The main pathophysiological features of type 2 diabetes mellitus are impaired insulin secretion and...
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Golestan University Of Medical Sciences
2024-12-01
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| Series: | Journal of Clinical and Basic Research |
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| Online Access: | http://jcbr.goums.ac.ir/article-1-382-en.pdf |
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| author | Dipalee Rahul Navale Vaishali Shashil Patil |
| author_facet | Dipalee Rahul Navale Vaishali Shashil Patil |
| author_sort | Dipalee Rahul Navale |
| collection | DOAJ |
| description | Background: Diabetes mellitus is an endocrine disorder. It is one of the leading causes of morbidity and mortality due to its role in the development of microvascular and macrovascular complications. The main pathophysiological features of type 2 diabetes mellitus are impaired insulin secretion and increased insulin resistance (IR). There is a relationship between fasting serum insulin, IR, and beta-cell dysfunction. Familial aggregation is a significant risk factor for early-onset type 2 diabetes mellitus. First-degree relatives not only share genetic predispositions but also socio-environmental risk factors like obesity and hyperglycemia, forming a high-risk group.
Methods: The study population consists of 60 people, including healthy controls (n = 20), first-degree relatives (n = 20), and diabetes patients (n = 20). The level of serum fasting insulin was measured by the chemiluminescence immunoassay method. IR was calculated using mathematical formulas such as HOMA-IR and HOMA-B.
Results: The results showed that the level of serum insulin increased in the FDR group (8.5 ± 5.6) compared to the diabetic and control groups (p < 0.001). HOMA-IR was significantly increased in individuals with diabetes (2.10 ± 1.10) and the FDR group (1.81 ± 1.25) compared to controls (p < 0.0001). We also noted a strong positive correlation between fasting serum insulin and HOMA-IR in the FDR group (r = +0.98) and in diabetic patients (r = +0.79).
Conclusion: Serum fasting insulin is an excellent and dependable marker for diagnosing IR in individuals at risk of developing diabetes, including FDR. |
| format | Article |
| id | doaj-art-5e7e142c5c4442e5a8bd560eaf01bcd3 |
| institution | OA Journals |
| issn | 2538-3736 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Golestan University Of Medical Sciences |
| record_format | Article |
| series | Journal of Clinical and Basic Research |
| spelling | doaj-art-5e7e142c5c4442e5a8bd560eaf01bcd32025-08-20T02:30:09ZengGolestan University Of Medical SciencesJournal of Clinical and Basic Research2538-37362024-12-01841921Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patientsDipalee Rahul Navale0Vaishali Shashil Patil1 Department of Biochemistry, D.Y. Patil Medical college and Hospital Kolhapur, Maharashtra, 416005, India Department of Biochemistry, D.Y. Patil Medical college and Hospital Kolhapur, Maharashtra, 416005, India Background: Diabetes mellitus is an endocrine disorder. It is one of the leading causes of morbidity and mortality due to its role in the development of microvascular and macrovascular complications. The main pathophysiological features of type 2 diabetes mellitus are impaired insulin secretion and increased insulin resistance (IR). There is a relationship between fasting serum insulin, IR, and beta-cell dysfunction. Familial aggregation is a significant risk factor for early-onset type 2 diabetes mellitus. First-degree relatives not only share genetic predispositions but also socio-environmental risk factors like obesity and hyperglycemia, forming a high-risk group. Methods: The study population consists of 60 people, including healthy controls (n = 20), first-degree relatives (n = 20), and diabetes patients (n = 20). The level of serum fasting insulin was measured by the chemiluminescence immunoassay method. IR was calculated using mathematical formulas such as HOMA-IR and HOMA-B. Results: The results showed that the level of serum insulin increased in the FDR group (8.5 ± 5.6) compared to the diabetic and control groups (p < 0.001). HOMA-IR was significantly increased in individuals with diabetes (2.10 ± 1.10) and the FDR group (1.81 ± 1.25) compared to controls (p < 0.0001). We also noted a strong positive correlation between fasting serum insulin and HOMA-IR in the FDR group (r = +0.98) and in diabetic patients (r = +0.79). Conclusion: Serum fasting insulin is an excellent and dependable marker for diagnosing IR in individuals at risk of developing diabetes, including FDR.http://jcbr.goums.ac.ir/article-1-382-en.pdfdiabetes mellitusfirst degree relatives |
| spellingShingle | Dipalee Rahul Navale Vaishali Shashil Patil Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients Journal of Clinical and Basic Research diabetes mellitus first degree relatives |
| title | Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients |
| title_full | Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients |
| title_fullStr | Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients |
| title_full_unstemmed | Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients |
| title_short | Evaluation of the serum fasting insulin and HOMA-IR in diabetic and FDR patients |
| title_sort | evaluation of the serum fasting insulin and homa ir in diabetic and fdr patients |
| topic | diabetes mellitus first degree relatives |
| url | http://jcbr.goums.ac.ir/article-1-382-en.pdf |
| work_keys_str_mv | AT dipaleerahulnavale evaluationoftheserumfastinginsulinandhomairindiabeticandfdrpatients AT vaishalishashilpatil evaluationoftheserumfastinginsulinandhomairindiabeticandfdrpatients |