Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages

Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages

IntroductionRecent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression of glutamatergic genes, mediating early neuronal damage.MethodsIn this study, we discovered that ch...

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Main Authors: Giacomo Siano, Martina Varisco, Marco Terrigno, Congwei Wang, Arianna Scarlatti, Vincenzo Iannone, Marco Groth, Marie-Christine Galas, Jeroen J. M. Hoozemans, Alessandro Cellerino, Antonino Cattaneo, Cristina Di Primio
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tau
Alzheimer’s disease
gene expression
chromatin remodeling
epigenetic markers
AD cellular model
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1459573/full
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