Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes
Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand compl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2017/6426747 |
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| author | Temitayo Aiyelabola Ezekiel Akinkunmi Efere Obuotor Idowu Olawuni David Isabirye Johan Jordaan |
| author_facet | Temitayo Aiyelabola Ezekiel Akinkunmi Efere Obuotor Idowu Olawuni David Isabirye Johan Jordaan |
| author_sort | Temitayo Aiyelabola |
| collection | DOAJ |
| description | Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity. |
| format | Article |
| id | doaj-art-5e74822db8de4029a93fa783c63fa94f |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-5e74822db8de4029a93fa783c63fa94f2025-02-03T01:21:24ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2017-01-01201710.1155/2017/64267476426747Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand ComplexesTemitayo Aiyelabola0Ezekiel Akinkunmi1Efere Obuotor2Idowu Olawuni3David Isabirye4Johan Jordaan5Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State, NigeriaDepartment of Chemistry, North-West University, Mafikeng Campus, Mmabatho, South AfricaFocus Area Chemical Resource Beneficiation, North-West University, Potchefstroom Campus, Potchefstroom, South AfricaCoordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.http://dx.doi.org/10.1155/2017/6426747 |
| spellingShingle | Temitayo Aiyelabola Ezekiel Akinkunmi Efere Obuotor Idowu Olawuni David Isabirye Johan Jordaan Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes Bioinorganic Chemistry and Applications |
| title | Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes |
| title_full | Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes |
| title_fullStr | Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes |
| title_full_unstemmed | Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes |
| title_short | Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes |
| title_sort | synthesis characterization and biological activities of coordination compounds of 4 hydroxy 3 nitro 2h chromen 2 one and its aminoethanoic acid and pyrrolidine 2 carboxylic acid mixed ligand complexes |
| url | http://dx.doi.org/10.1155/2017/6426747 |
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