Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies

Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies

ObjectivesBased on clinical, biomarker, and genetic data, McGonagle and McDermott suggested that autoimmune and autoinflammatory disorders can be classified as a disease continuum from purely autoimmune to autoinflammatory with mixed diseases in between. However, the genetic architecture of this spe...

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Bibliographic Details
Main Authors: Vera Fominykh, Alexey A. Shadrin, Piotr Jaholkowski, Julian Fuhrer, Nadine Parker, Erik D. Wiström, Oleksandr Frei, Olav B. Smeland, Helga Sanner, Srdjan Djurovic, Ole A. Andreassen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
inflammation
autoimmune diseases
genome-wide association studies
polygenicity
classification
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1543781/full
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