Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report
Immune checkpoint inhibitors, such as pembrolizumab, have demonstrated substantial therapeutic efficacy in the treatment of cancer. However, immune-related adverse events, including myasthenia gravis (MG), present significant clinical challenges. This study presents the case of a 75-year-old male pa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-04-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/17562864251333518 |
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| author | Ying Huang Futian Wu Yihan Xiong Kangling Huang Xin Chang Xiaofeng Chen Xiali Chen Qiwen Zhang Liangyu Zou Xuejun Fu Huadong Zhang Qianhui Xu |
| author_facet | Ying Huang Futian Wu Yihan Xiong Kangling Huang Xin Chang Xiaofeng Chen Xiali Chen Qiwen Zhang Liangyu Zou Xuejun Fu Huadong Zhang Qianhui Xu |
| author_sort | Ying Huang |
| collection | DOAJ |
| description | Immune checkpoint inhibitors, such as pembrolizumab, have demonstrated substantial therapeutic efficacy in the treatment of cancer. However, immune-related adverse events, including myasthenia gravis (MG), present significant clinical challenges. This study presents the case of a 75-year-old male patient who developed generalized acetylcholine receptor antibody-positive MG following the first infusion of pembrolizumab for cholangiocarcinoma. The patient’s symptoms rapidly progressed to an impending myasthenic crisis (MGFA Class IVB) within 20 days of pembrolizumab administration. Eculizumab was used as a rescue therapy due to the unavailability of conventional treatments, resulting in rapid and significant symptom relief, with sustained improvement during maintenance therapy. The use of eculizumab as rescue therapy presents a viable treatment option for pembrolizumab-induced MG, owing to its rapid therapeutic effects. |
| format | Article |
| id | doaj-art-5e6deab00a3b476d88601f51bacc92b4 |
| institution | OA Journals |
| issn | 1756-2864 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj-art-5e6deab00a3b476d88601f51bacc92b42025-08-20T02:19:38ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28642025-04-011810.1177/17562864251333518Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case reportYing HuangFutian WuYihan XiongKangling HuangXin ChangXiaofeng ChenXiali ChenQiwen ZhangLiangyu ZouXuejun FuHuadong ZhangQianhui XuImmune checkpoint inhibitors, such as pembrolizumab, have demonstrated substantial therapeutic efficacy in the treatment of cancer. However, immune-related adverse events, including myasthenia gravis (MG), present significant clinical challenges. This study presents the case of a 75-year-old male patient who developed generalized acetylcholine receptor antibody-positive MG following the first infusion of pembrolizumab for cholangiocarcinoma. The patient’s symptoms rapidly progressed to an impending myasthenic crisis (MGFA Class IVB) within 20 days of pembrolizumab administration. Eculizumab was used as a rescue therapy due to the unavailability of conventional treatments, resulting in rapid and significant symptom relief, with sustained improvement during maintenance therapy. The use of eculizumab as rescue therapy presents a viable treatment option for pembrolizumab-induced MG, owing to its rapid therapeutic effects.https://doi.org/10.1177/17562864251333518 |
| spellingShingle | Ying Huang Futian Wu Yihan Xiong Kangling Huang Xin Chang Xiaofeng Chen Xiali Chen Qiwen Zhang Liangyu Zou Xuejun Fu Huadong Zhang Qianhui Xu Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report Therapeutic Advances in Neurological Disorders |
| title | Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report |
| title_full | Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report |
| title_fullStr | Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report |
| title_full_unstemmed | Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report |
| title_short | Eculizumab as fast-acting rescue therapy for pembrolizumab-induced impending crisis state of myasthenia gravis: a case report |
| title_sort | eculizumab as fast acting rescue therapy for pembrolizumab induced impending crisis state of myasthenia gravis a case report |
| url | https://doi.org/10.1177/17562864251333518 |
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