Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin
Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Cli...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2014/860804 |
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| author | Jôice Dias Corrêa Amanda Leal Rocha Lidiane Cristina Machado Costa Denise Travassos Wagner Henriques Castro Gustavo Pompermaier Garlet Rodrigo Santiago Gomez Antônio Lúcio Teixeira Tarcília Aparecida Silva |
| author_facet | Jôice Dias Corrêa Amanda Leal Rocha Lidiane Cristina Machado Costa Denise Travassos Wagner Henriques Castro Gustavo Pompermaier Garlet Rodrigo Santiago Gomez Antônio Lúcio Teixeira Tarcília Aparecida Silva |
| author_sort | Jôice Dias Corrêa |
| collection | DOAJ |
| description | Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts. In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation. |
| format | Article |
| id | doaj-art-5e689f632211426c935142e9ff938322 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-5e689f632211426c935142e9ff9383222025-02-03T05:48:23ZengWileyCase Reports in Dentistry2090-64472090-64552014-01-01201410.1155/2014/860804860804Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous ImmunoglobulinJôice Dias Corrêa0Amanda Leal Rocha1Lidiane Cristina Machado Costa2Denise Travassos3Wagner Henriques Castro4Gustavo Pompermaier Garlet5Rodrigo Santiago Gomez6Antônio Lúcio Teixeira7Tarcília Aparecida Silva8Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilSpecial Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilSpecial Service for Diagnosis and Treatment in Dentistry (SEDTO), Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilDepartment of Biological Sciences, Bauru School of Dentistry, University of São Paulo, 17012-901 Bauru, SP, BrazilNeurology Service, Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, BrazilNeurology Service, Hospital and Clinics, Federal University of Minas Gerais, 30130-100 Belo Horizonte, MG, BrazilDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, BrazilIntravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts. In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation.http://dx.doi.org/10.1155/2014/860804 |
| spellingShingle | Jôice Dias Corrêa Amanda Leal Rocha Lidiane Cristina Machado Costa Denise Travassos Wagner Henriques Castro Gustavo Pompermaier Garlet Rodrigo Santiago Gomez Antônio Lúcio Teixeira Tarcília Aparecida Silva Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin Case Reports in Dentistry |
| title | Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin |
| title_full | Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin |
| title_fullStr | Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin |
| title_full_unstemmed | Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin |
| title_short | Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin |
| title_sort | severe periodontal disease associated with long term treatment with intravenous immunoglobulin |
| url | http://dx.doi.org/10.1155/2014/860804 |
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