Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma

Periostin-mediated activation of NF-κB signaling promotes tumor progression and chemoresistance in glioblastoma

Abstract Glioblastoma (GBM) is the most aggressive form of diffuse glioma, characterized by high lethality. Temozolomide (TMZ)-based chemotherapy is a standard treatment for GBM, but development of chemoresistance poses a significant therapeutic challenge. Despite advances in understanding GBM biolo...

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Bibliographic Details
Main Authors: Yu Shang, Yuxia Liang, Beichen Zhang, Wei Wu, Yihao Peng, Jin Wang, Ming Zhang, Chen Niu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
EMT-related phenotypes
NF-κB signaling
TMZ resistance
POSTN
Glioblastoma
Online Access:https://doi.org/10.1038/s41598-025-92969-8
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