Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test
BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2015/902914 |
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| _version_ | 1832549855067635712 |
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| author | Handong Ouyang Peizong Wang Wan Huang Qiang Li Bilin Nie Weian Zeng |
| author_facet | Handong Ouyang Peizong Wang Wan Huang Qiang Li Bilin Nie Weian Zeng |
| author_sort | Handong Ouyang |
| collection | DOAJ |
| description | BACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding and function, acting via the allosteric site on the α2A-adrenergic receptor. |
| format | Article |
| id | doaj-art-5e65735eabc140e2b4d2f7799890776a |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-5e65735eabc140e2b4d2f7799890776a2025-02-03T06:08:21ZengWileyPain Research and Management1203-67652015-01-0120632132610.1155/2015/902914Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin TestHandong Ouyang0Peizong Wang1Wan Huang2Qiang Li3Bilin Nie4Weian Zeng5Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaDepartment of Anesthesiology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, ChinaBACKGROUND: Amiloride has been reported to produce a wide variety of actions, thereby affecting several ionic channels and a multitude of receptors and enzymes. Intrathecal α2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates α2-adrenergic receptor agonist binding and function, acting via the allosteric site on the α2A-adrenergic receptor.http://dx.doi.org/10.1155/2015/902914 |
| spellingShingle | Handong Ouyang Peizong Wang Wan Huang Qiang Li Bilin Nie Weian Zeng Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test Pain Research and Management |
| title | Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test |
| title_full | Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test |
| title_fullStr | Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test |
| title_full_unstemmed | Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test |
| title_short | Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test |
| title_sort | spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test |
| url | http://dx.doi.org/10.1155/2015/902914 |
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