Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease
An early diagnosis is required for intervention in prion disease cases. To elucidate the specificity of early electroencephalography discharges in cases of sporadic Creutzfeldt-Jakob disease, we analysed epileptiform discharges through electroencephalography. Nine patients with methionine/methionine...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Prion |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336896.2025.2483215 |
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| author | Taiki Matsubayashi Hirokazu Natsui Katsuya Satoh Tetsuyuki Kitamoto Takanori Yokota Nobuo Sanjo |
| author_facet | Taiki Matsubayashi Hirokazu Natsui Katsuya Satoh Tetsuyuki Kitamoto Takanori Yokota Nobuo Sanjo |
| author_sort | Taiki Matsubayashi |
| collection | DOAJ |
| description | An early diagnosis is required for intervention in prion disease cases. To elucidate the specificity of early electroencephalography discharges in cases of sporadic Creutzfeldt-Jakob disease, we analysed epileptiform discharges through electroencephalography. Nine patients with methionine/methionine type 1/classic sporadic Creutzfeldt-Jakob disease and 20 patients with status epilepticus were included. Generalized periodic discharges, lateralized periodic discharges, and central sagittal sporadic epileptiform discharges were evaluated. Central sagittal sporadic epileptiform discharges were defined as nonrhythmic and nonperiodic waveforms showing generalized spike-and-wave complexes and/or sharp waves predominantly in the central sagittal region. In the sporadic Creutzfeldt-Jakob disease group, central sagittal sporadic epileptiform discharges, lateralized periodic discharges, and generalized periodic discharges were observed in five (55.6%), one (11.1%), and eight (88.9%) patients, respectively, with an average duration from onset to the appearance of the discharges of 1.6, 1.0, and 2.44 months, respectively. In the status epilepticus group, these discharges were detected in one (5.0%), six (30.0%), and six (30.0%) patients, respectively. The incorporation of central sagittal sporadic epileptiform discharges and lateralized periodic discharges into the World Health Organization diagnostic criteria, alongside generalized periodic discharges, significantly shortened the average lapse from symptom onset to sporadic Creutzfeldt-Jakob disease diagnosis (2.06 months vs. 2.44 months; p = 0.02). Central sagittal sporadic epileptiform discharges emerge as promising biomarkers for distinguishing sporadic Creutzfeldt-Jakob disease from status epilepticus, and together with lateralized periodic discharges provide an opportunity for early diagnosis of sporadic Creutzfeldt-Jakob disease. |
| format | Article |
| id | doaj-art-5e64f6b22c3c4d87a3c728c970f00eb7 |
| institution | Kabale University |
| issn | 1933-6896 1933-690X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Prion |
| spelling | doaj-art-5e64f6b22c3c4d87a3c728c970f00eb72025-08-20T03:41:43ZengTaylor & Francis GroupPrion1933-68961933-690X2025-12-01191172410.1080/19336896.2025.2483215Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob diseaseTaiki Matsubayashi0Hirokazu Natsui1Katsuya Satoh2Tetsuyuki Kitamoto3Takanori Yokota4Nobuo Sanjo5Department of Neurology and Neurological Science, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Tokyo, JapanDepartment of Neurology and Neurological Science, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Tokyo, JapanDepartment of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanDepartment of Neurological Science, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurology and Neurological Science, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Tokyo, JapanDepartment of Neurology and Neurological Science, Institute of Science Tokyo Graduate School of Medical and Dental Sciences, Tokyo, JapanAn early diagnosis is required for intervention in prion disease cases. To elucidate the specificity of early electroencephalography discharges in cases of sporadic Creutzfeldt-Jakob disease, we analysed epileptiform discharges through electroencephalography. Nine patients with methionine/methionine type 1/classic sporadic Creutzfeldt-Jakob disease and 20 patients with status epilepticus were included. Generalized periodic discharges, lateralized periodic discharges, and central sagittal sporadic epileptiform discharges were evaluated. Central sagittal sporadic epileptiform discharges were defined as nonrhythmic and nonperiodic waveforms showing generalized spike-and-wave complexes and/or sharp waves predominantly in the central sagittal region. In the sporadic Creutzfeldt-Jakob disease group, central sagittal sporadic epileptiform discharges, lateralized periodic discharges, and generalized periodic discharges were observed in five (55.6%), one (11.1%), and eight (88.9%) patients, respectively, with an average duration from onset to the appearance of the discharges of 1.6, 1.0, and 2.44 months, respectively. In the status epilepticus group, these discharges were detected in one (5.0%), six (30.0%), and six (30.0%) patients, respectively. The incorporation of central sagittal sporadic epileptiform discharges and lateralized periodic discharges into the World Health Organization diagnostic criteria, alongside generalized periodic discharges, significantly shortened the average lapse from symptom onset to sporadic Creutzfeldt-Jakob disease diagnosis (2.06 months vs. 2.44 months; p = 0.02). Central sagittal sporadic epileptiform discharges emerge as promising biomarkers for distinguishing sporadic Creutzfeldt-Jakob disease from status epilepticus, and together with lateralized periodic discharges provide an opportunity for early diagnosis of sporadic Creutzfeldt-Jakob disease.https://www.tandfonline.com/doi/10.1080/19336896.2025.2483215Central sagittal sporadic epileptiform dischargeselectroencephalogramlateralized periodic dischargessporadic creutzfeldt–jakob diseasestatus epilepticus |
| spellingShingle | Taiki Matsubayashi Hirokazu Natsui Katsuya Satoh Tetsuyuki Kitamoto Takanori Yokota Nobuo Sanjo Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease Prion Central sagittal sporadic epileptiform discharges electroencephalogram lateralized periodic discharges sporadic creutzfeldt–jakob disease status epilepticus |
| title | Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease |
| title_full | Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease |
| title_fullStr | Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease |
| title_full_unstemmed | Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease |
| title_short | Specific early electroencephalogram for the diagnosis of sporadic Creutzfeldt-Jakob disease |
| title_sort | specific early electroencephalogram for the diagnosis of sporadic creutzfeldt jakob disease |
| topic | Central sagittal sporadic epileptiform discharges electroencephalogram lateralized periodic discharges sporadic creutzfeldt–jakob disease status epilepticus |
| url | https://www.tandfonline.com/doi/10.1080/19336896.2025.2483215 |
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