PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate
Abstract Emerging evidence indicates that metabolic signals—including nutrient availability, biosynthetic intermediates, and energy balance—are linked to cell cycle progression. However, how these signals are sensed by the cell cycle machinery remains unclear. Citrate, a key intermediate in the TCA...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62111-3 |
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